Syprine, Cuprior(trientine)
Cufence, Cuprior, Syprine, Trientine (trientine) is a small molecule pharmaceutical. Trientine was first approved as Syprine on 1985-11-08. It is used to treat hepatolenticular degeneration and nervous system heavy metal poisoning in the USA. It has been approved in Europe to treat hepatolenticular degeneration.
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Commercial
Trade Name
FDA
EMA
Cuvrior, Syprine, Trientine (discontinued: Clovique, Trientine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trientine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SYPRINE | Bausch Health Companies | N-019194 RX | 1985-11-08 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cuvrior | New Drug Application | 2024-01-31 |
| syprine | New Drug Application | 2020-09-01 |
| trientine hydrochloride | ANDA | 2023-05-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hepatolenticular degeneration | Orphanet_905 | D006527 | E83.01 |
| nervous system heavy metal poisoning | EFO_1001815 | D020260 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatolenticular degeneration | D006527 | Orphanet_905 | E83.01 | 2 | — | 4 | 1 | 6 | 13 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Macular edema | D008269 | — | — | — | 1 | — | — | 1 | 2 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | 1 | — | — | — | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | — | — | — | 1 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | 1 | — | — | — | 1 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | 1 | — | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 1 | — | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | — | 1 | — | — | — | 1 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 1 | — | — | — | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 1 | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trientine |
| INN | trientine |
| Description | 2,2,2-tetramine is a polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. It has a role as a copper chelator. It is a tetramine and a polyazaalkane. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCNCCNCCN |
Identifiers
| PDB | — |
| CAS-ID | 112-24-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL609 |
| ChEBI ID | 39501 |
| PubChem CID | 5565 |
| DrugBank | DB06824 |
| UNII ID | SJ76Y07H5F (ChemIDplus, GSRS) |
Target
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Financial
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Clovique – Sanofi
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Trends
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Additional graphs summarizing 1,205 documents
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Safety
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Adverse Events
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244 adverse events reported
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