Triclabendazole
Egaten (triclabendazole) is a small molecule pharmaceutical. Triclabendazole was first approved as Egaten on 2019-02-13. It is used to treat fascioliasis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
Egaten
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| egaten | New Drug Application | 2024-07-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| fascioliasis | EFO_1001324 | D005211 | B66.3 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TRICLABENDAZOLE, EGATEN, NOVARTIS | |||
| 2026-02-13 | ODE-228 | ||
| 2024-02-13 | NCE | ||
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fascioliasis | D005211 | EFO_1001324 | B66.3 | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triclabendazole |
| INN | triclabendazole |
| Description | 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole is an aromatic ether. |
| Classification | Small molecule |
| Drug class | antithelmintics (tibendazole type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSc1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 68786-66-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1086440 |
| ChEBI ID | — |
| PubChem CID | 50248 |
| DrugBank | DB12245 |
| UNII ID | 4784C8E03O (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,146 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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27 adverse events reported
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