Triapine
Triapine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lbel effet parfait signs of age appearance minimizer foundation spf 20 fm | OTC monograph final | 2019-12-03 |
| lbel effet parfait signs of age appearance minimizer foundation spf 20 fm claire 2 lbel effet parfait signs of age appearance minimizer foundation ... | OTC monograph final | 2021-07-29 |
Indications
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Agency Specific
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Clinical
Clinical Trials
208 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 1 | — | — | — | 1 |
| Combination drug therapy | D004359 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triapine |
| INN | — |
| Description | 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is substance of interest for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
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| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=S)N/N=C/c1ncccc1N |
Identifiers
| PDB | — |
| CAS-ID | 143621-35-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL231616 |
| ChEBI ID | — |
| PubChem CID | 9571836 |
| DrugBank | — |
| UNII ID | — |
Target
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Variants
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Safety
Black-box Warning
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Adverse Events
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