Triapine
Triapine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lbel effet parfait signs of age appearance minimizer foundation spf 20 fm | OTC monograph final | 2019-12-03 |
| lbel effet parfait signs of age appearance minimizer foundation spf 20 fm claire 2 lbel effet parfait signs of age appearance minimizer foundation ... | OTC monograph final | 2021-07-29 |
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Agency Specific
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Clinical
Clinical Trials
210 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Whooping cough | D014917 | EFO_0000650 | A37 | 2 | — | 2 | 1 | 5 | 10 |
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | 7 | 1 | — | 8 |
| Pruritus | D011537 | — | L29 | — | — | 5 | 1 | 1 | 7 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 3 | 1 | 1 | — | 6 |
| Diphtheria | D004165 | EFO_0005549 | A36 | 1 | — | 2 | 1 | — | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 1 | 1 | 2 | 4 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | 1 | 3 | 4 |
| Malaria | D008288 | EFO_0001068 | B54 | 1 | — | — | 2 | — | 3 |
| Tetanus | D013742 | EFO_0005593 | A35 | 1 | — | 1 | 1 | — | 3 |
| Chronic pain | D059350 | — | — | — | — | — | 1 | 2 | 3 |
Show 15 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 10 | 7 | 1 | — | — | 16 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | 1 | — | 11 | 14 |
| Neoplasms | D009369 | — | C80 | 8 | 2 | 1 | — | 2 | 12 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | 5 | 1 | — | — | 10 |
| Myeloid leukemia | D007951 | — | C92 | 4 | 5 | 1 | — | — | 10 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | 7 | — | 1 | 9 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | — | 8 | 9 |
| Carcinoma | D002277 | — | C80.0 | 2 | 3 | 1 | — | 1 | 7 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | 7 | — | — | 7 |
| Adenocarcinoma | D000230 | — | — | 2 | 3 | 1 | — | 1 | 7 |
Show 38 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 5 | — | — | 1 | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 4 | 6 | — | — | — | 8 |
| Recurrence | D012008 | — | — | 4 | 3 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 4 | 3 | — | — | — | 5 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 3 | 1 | — | — | — | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 2 | — | — | — | 4 |
| Syndrome | D013577 | — | — | 3 | 1 | — | — | 1 | 4 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 1 | 2 | — | — | — | 3 |
| Blast crisis | D001752 | — | — | 1 | 2 | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | — | 3 |
Show 54 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 1 | — | — | — | 2 | 3 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | 1 | — | — | — | 2 | 3 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 2 | — | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Gene rearrangement | D015321 | — | — | 1 | — | — | — | — | 1 |
| Trismus | D014313 | — | — | 1 | — | — | — | — | 1 |
| Tetany | D013746 | — | P71.3 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
Show 24 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 8 | 8 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 5 | 5 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 3 | 3 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 3 | 3 |
| Radiculopathy | D011843 | — | M54.1 | — | — | — | — | 3 | 3 |
| Bursitis | D002062 | EFO_1000941 | M71.9 | — | — | — | — | 3 | 3 |
| Intervertebral disc degeneration | D055959 | — | — | — | — | — | — | 2 | 2 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | — | — | — | — | 2 | 2 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | — | — | — | — | 2 | 2 |
| Sprains and strains | D013180 | — | — | — | — | — | — | 2 | 2 |
Show 97 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triapine |
| INN | — |
| Description | 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is substance of interest for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
|
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=S)N/N=C/c1ncccc1N |
Identifiers
| PDB | — |
| CAS-ID | 143621-35-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL231616 |
| ChEBI ID | — |
| PubChem CID | 9571836 |
| DrugBank | — |
| UNII ID | — |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
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