Triamterene
Dyrenium, Maxzide, Triamterene (triamterene) is a small molecule pharmaceutical. Triamterene was first approved as Dyazide on 1982-01-01. It is used to treat edema, hypertension, and hypokalemia in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Dyrenium (generic drugs available since 1988-04-17)
CombinationsMaxzide (generic drugs available since 1988-04-17, discontinued: Dyazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrochlorothiazide
+
Triamterene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MAXZIDE-25 | Aurobindo Pharma | N-019129 RX | 1988-05-13 | 1 products, RLD |
| MAXZIDE | Aurobindo Pharma | N-019129 RX | 1984-10-22 | 1 products, RLD, RS |
Show 1 discontinued
Triamterene
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DYRENIUM | Concordia Laboratories | N-013174 RX | 1982-01-01 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antiseptic skin cleanser | New Drug Application | 2024-02-13 |
| maxzide maxzide-25 | New Drug Application | 2022-04-07 |
| rugby petrolatum hydrating | C200263 | 2024-02-12 |
| triamterene and hydrochlorothiazide | ANDA | 2024-01-31 |
| triamterene hydrochlorothiazide | ANDA | 2017-12-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| edema | — | D004487 | R60.9 |
| hypertension | EFO_0000537 | D006973 | I10 |
| hypokalemia | HP_0002900 | D007008 | E87.6 |
Agency Specific
FDA
EMA
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Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 2 | — | 4 | 6 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 2 | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 1 | — | — | 1 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | — | 1 |
| Coronary disease | D003327 | — | — | — | — | 1 | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 1 | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | 1 | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triamterene |
| INN | triamterene |
| Description | Triamterene is pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema. It has a role as a diuretic and a sodium channel blocker. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1 |
Identifiers
| PDB | — |
| CAS-ID | 396-01-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL585 |
| ChEBI ID | — |
| PubChem CID | 5546 |
| DrugBank | DB00384 |
| UNII ID | WS821Z52LQ (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Triamterene
+
Hydrochlorothiazide
Total medical expenditures per year (USD, in millions)
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Triamterene
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Trends
PubMed Central
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Safety
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Adverse Events
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2,514 adverse events reported
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