Treosulfan
Trecondi (treosulfan) is a small molecule pharmaceutical. Treosulfan was first approved as Trecondi on 2019-06-20. It has been approved in Europe to treat hematopoietic stem cell transplantation.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| therapeutics | D013812 |
| operative surgical procedures | D013514 |
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Drug Products
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Indications
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Agency Specific
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 5 | 1 | — | — | 7 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 4 | 1 | — | — | 6 |
| Melanoma | D008545 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Preleukemia | D011289 | — | — | 2 | 4 | — | — | — | 5 |
| Leukemia | D007938 | — | C95 | 1 | 4 | — | — | — | 4 |
| Hematologic neoplasms | D019337 | — | — | 1 | 3 | — | — | — | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | 3 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | — | 2 | — | — | — | 2 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | — | 2 | — | — | — | 2 |
| Syndrome | D013577 | — | — | 1 | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematopoietic stem cell transplantation | D018380 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Treosulfan |
| INN | treosulfan |
| Description | Treosulfan is a methanesulfonate ester. |
| Classification | Small molecule |
| Drug class | antineoplastics, alkylating agents (methane sulfonate derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 299-75-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL455186 |
| ChEBI ID | 82557 |
| PubChem CID | 9882105 |
| DrugBank | DB11678 |
| UNII ID | CO61ER3EPI (ChemIDplus, GSRS) |
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Safety
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4,102 adverse events reported
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