Grafapex, Trecondi(treosulfan)
Grafapex, Trecondi (treosulfan) is a small molecule pharmaceutical. Treosulfan was first approved as Trecondi on 2019-06-20. It has been approved in Europe to treat hematopoietic stem cell transplantation.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| therapeutics | D013812 |
| operative surgical procedures | D013514 |
Trade Name
FDA
EMA
Grafapex
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Treosulfan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| GRAFAPEX | Medexus Pharmaceuticals | N-214759 RX | 2025-01-21 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| grafapex | New Drug Application | 2025-01-31 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
51 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | — | 1 | — | — | — | 1 |
| Preleukemia | D011289 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Treosulfan |
| INN | treosulfan |
| Description | Treosulfan is a methanesulfonate ester. |
| Classification | Small molecule |
| Drug class | antineoplastics, alkylating agents (methane sulfonate derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 299-75-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL455186 |
| ChEBI ID | 82557 |
| PubChem CID | 9882105 |
| DrugBank | DB11678 |
| UNII ID | CO61ER3EPI (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,803 documents
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Safety
Black-box Warning
Black-box warning for: Grafapex
Adverse Events
Top Adverse Reactions
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4,220 adverse events reported
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