Trazodone
Raldesy, Trazodone (trazodone) is a small molecule pharmaceutical. Trazodone was first approved as Desyrel on 1982-01-01. It is used to treat depressive disorder and sleep initiation and maintenance disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A. In addition, it is known to target 5-hydroxytryptamine receptor 2B.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Trazodone (discontinued: Desyrel, Oleptro, Trazodone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trazodone hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| OLEPTRO | Angelini Pharma | N-022411 DISCN | 2010-02-02 | 2 products, RLD |
| DESYREL | Pragma Pharmaceuticals | N-018207 DISCN | 1982-01-01 | 4 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| desyrel | ANDA | 2010-01-22 |
| raldesy | New Drug Application | 2025-04-04 |
| trazamine | unapproved drug other | 2011-08-01 |
| trazodone hcl | ANDA | 2024-12-31 |
| trazodone hydrochloride | ANDA | 2025-10-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| sleep initiation and maintenance disorders | — | D007319 | F51.01 |
| depressive disorder | EFO_1002014 | D003866 | F32.A |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
76 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 3 | 3 | 4 | 2 | 6 | 17 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | 1 | 3 | 3 | 3 | 11 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 3 | 2 | — | 5 | 1 | 10 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | 3 | 1 | 3 | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 2 | 2 | 2 | 2 | 8 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 4 | 2 | — | 3 | 1 | 8 |
| Apnea | D001049 | — | R06.81 | 1 | — | — | 3 | 1 | 5 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | 1 | 1 | 1 | 4 |
| Sleep wake disorders | D012893 | — | G47 | — | 1 | 2 | 1 | — | 4 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | 1 | 1 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parasomnias | D020447 | — | G47.5 | — | 2 | 2 | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 2 | — | — | 2 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | 1 | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | 1 | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | 1 | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | 1 | 2 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 2 | — | — | — | 2 |
| Hypokinesia | D018476 | — | — | 1 | 1 | — | — | — | 1 |
| Psychological sexual dysfunctions | D020018 | — | F52.0 | 1 | 1 | — | — | — | 1 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | 1 | — | — | — | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | — | — | — | 1 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | — | — | — | 1 |
| Dyssomnias | D020920 | — | — | — | 1 | — | — | — | 1 |
| Amnesia | D000647 | EFO_1001454 | F44.0 | — | 1 | — | — | — | 1 |
| Drug therapy | D004358 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 4 | — | — | — | 1 | 5 |
| Traumatic stress disorders | D040921 | — | — | 2 | — | — | — | — | 2 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | — | 1 | 1 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 1 | 1 |
| Chronic disease | D002908 | — | — | — | — | — | — | 1 | 1 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 1 | 1 |
| Alcohol-related disorders | D019973 | — | F10 | — | — | — | — | 1 | 1 |
| Suicidal ideation | D059020 | EFO_0004320 | R45.851 | — | — | — | — | 1 | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | — | — | — | — | 1 | 1 |
| Problem behavior | D000066553 | — | — | — | — | — | — | 1 | 1 |
| Physiological sexual dysfunction | D012735 | — | — | — | — | — | — | 1 | 1 |
Show 4 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Trazodone |
| INN | trazodone |
| Description | Trazodone is an N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group. It has a role as an antidepressant, a sedative, an adrenergic antagonist, a H1-receptor antagonist, a serotonin uptake inhibitor and an anxiolytic drug. It is a N-alkylpiperazine, a N-arylpiperazine, a triazolopyridine and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1n(CCCN2CCN(c3cccc(Cl)c3)CC2)nc2ccccn12 |
Identifiers
| PDB | — |
| CAS-ID | 19794-93-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL621 |
| ChEBI ID | 9654 |
| PubChem CID | 5533 |
| DrugBank | DB00656 |
| UNII ID | YBK48BXK30 (ChemIDplus, GSRS) |
Target
Agency Approved
HTR2C
HTR2C
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR2C
Gene synonyms
HTR1C
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2C
Protein synonyms
5-HT-1C, 5-HT1C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, serotonin 5-HT-1C receptor, serotonin 5-HT-2C receptor, Serotonin receptor 2C
Uniprot ID
Mouse ortholog
Htr2c (15560)
5-hydroxytryptamine receptor 2C (Q5WRU6)
Alternate
HTR2B
HTR2B
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Trazodone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,626 documents
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Safety
Black-box Warning
Black-box warning for: Desyrel, Raldesy, Trazodone hcl, Trazodone hydrochloride
Adverse Events
Top Adverse Reactions
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25,966 adverse events reported
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