Tranylcypromine
Parnate, Tranylcypromine (tranylcypromine) is a small molecule pharmaceutical. Tranylcypromine was first approved as Parnate on 1985-08-16. It is used to treat depressive disorder and post-traumatic stress disorders in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] A and amine oxidase [flavin-containing] B. In addition, it is known to target lysine-specific histone demethylase 1A and prostacyclin synthase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Parnate, Tranylcypromine
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tranylcypromine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PARNATE | ADVANZ PHARMA | N-012342 RX | 1985-08-16 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| parnate | New Drug Application | 2024-12-05 |
| tranylcypromine | ANDA | 2024-12-20 |
| tranylcypromine sulfate | ANDA | 2023-05-26 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| post-traumatic stress disorders | EFO_0001358 | D013313 | F43.1 |
| depressive disorder | EFO_1002014 | D003866 | F32.A |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
34 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 2 | 1 | — | 5 | 3 | 10 |
| Depression | D003863 | — | F33.9 | 1 | — | 1 | 5 | 2 | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 2 | 1 | — | 3 | 2 | 7 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 2 | 2 | 2 | 6 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | 3 | 2 | 5 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 4 | — | 4 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 2 | 1 | 3 |
| Atrophy | D001284 | — | — | — | — | — | 1 | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | — | 1 | — | 1 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | — | — | 1 |
| Hemorrhagic stroke | D000083302 | — | — | — | — | 1 | — | — | 1 |
| Gastrointestinal hemorrhage | D006471 | HP_0002239 | K92.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 1 | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
| Melanosis | D008548 | HP_0001480 | L81.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 1 | 1 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | — | — | — | 1 | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 1 | 1 |
| Postoperative hemorrhage | D019106 | — | — | — | — | — | — | 1 | 1 |
| Surgical blood loss | D016063 | — | — | — | — | — | — | 1 | 1 |
| Leiomyoma | D007889 | HP_0000131 | D25 | — | — | — | — | 1 | 1 |
| Myofibroma | D047708 | — | — | — | — | — | — | 1 | 1 |
| Ear diseases | D004427 | EFO_1001455 | H93.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tranylcypromine |
| INN | tranylcypromine |
| Description | (1R,2S)-tranylcypromine is a 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. It is a conjugate base of a (1R,2S)-tranylcypromine(1+). It is an enantiomer of a (1S,2R)-tranylcypromine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 155-09-9 |
| RxCUI | 10734 |
| ChEMBL ID | CHEMBL3989843 |
| ChEBI ID | — |
| PubChem CID | 19493 |
| DrugBank | DB00752 |
| UNII ID | 3E3V44J4Z9 (ChemIDplus, GSRS) |
Target
Alternate
KDM1A
KDM1A
PTGIS
PTGIS
Organism
Homo sapiens
Gene name
KDM1A
Gene synonyms
AOF2, KDM1, KIAA0601, LSD1
NCBI Gene ID
Protein name
lysine-specific histone demethylase 1A
Protein synonyms
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A, amine oxidase (flavin containing) domain 2, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, Flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1A, lysine-specific histone demethylase 1
Uniprot ID
Mouse ortholog
Kdm1a (99982)
lysine-specific histone demethylase 1A (Q8VEA1)
Variants
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Financial
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Estimated US medical usage
Tranylcypromine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Parnate, Tranylcypromine, Tranylcypromine sulfate
Adverse Events
Top Adverse Reactions
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873 adverse events reported
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