Tranylcypromine
Parnate (tranylcypromine) is a small molecule pharmaceutical. Tranylcypromine was first approved as Parnate on 1985-08-16. It is used to treat depressive disorder and post-traumatic stress disorders in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] B and amine oxidase [flavin-containing] A. In addition, it is known to target lysine-specific histone demethylase 1A and prostacyclin synthase.
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Completion date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Parnate (generic drugs available since 2006-06-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tranylcypromine sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PARNATE | Concordia Laboratories | N-012342 RX | 1985-08-16 | 1 products, RLD, RS |
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| depressive disorder | EFO_1002014 | D003866 | F32.A |
| post-traumatic stress disorders | EFO_0001358 | D013313 | F43.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 2 | 1 | — | 1 | 2 | 5 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 4 | — | 4 |
| Depression | D003863 | — | F33.9 | — | — | 1 | 1 | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | 1 | 2 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | 1 | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
| Panic disorder | D016584 | EFO_0004262 | F41.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | — | — | 1 |
| Hemorrhagic stroke | D000083302 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 1 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Melanosis | D008548 | HP_0001480 | L81.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | — | 2 | 2 |
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 1 | 1 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 1 | 1 |
| Postoperative hemorrhage | D019106 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tranylcypromine |
| INN | tranylcypromine |
| Description | (1R,2S)-tranylcypromine is a 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. It is a conjugate base of a (1R,2S)-tranylcypromine(1+). It is an enantiomer of a (1S,2R)-tranylcypromine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 155-09-9 |
| RxCUI | 10734 |
| ChEMBL ID | CHEMBL3989843 |
| ChEBI ID | — |
| PubChem CID | 19493 |
| DrugBank | DB00752 |
| UNII ID | 3E3V44J4Z9 (ChemIDplus, GSRS) |
Target
Agency Approved
MAOB
MAOB
MAOA
MAOA
Alternate
KDM1A
KDM1A
PTGIS
PTGIS
Organism
Homo sapiens
Gene name
KDM1A
Gene synonyms
AOF2, KDM1, KIAA0601, LSD1
NCBI Gene ID
Protein name
lysine-specific histone demethylase 1A
Protein synonyms
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A, amine oxidase (flavin containing) domain 2, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, Flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific demethylase 1A, lysine-specific histone demethylase 1
Uniprot ID
Mouse ortholog
Kdm1a (99982)
lysine-specific histone demethylase 1A (Q8VEA1)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Tranylcypromine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,397 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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756 adverse events reported
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