Transplatin
Transplatin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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FDA
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Brand Name | Status | Last Update |
|---|---|---|
| cisplatin | ANDA | 2024-02-12 |
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Clinical
Clinical Trials
4413 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 114 | 330 | 178 | 20 | 33 | 619 |
| Head and neck neoplasms | D006258 | — | — | 67 | 166 | 61 | 2 | 19 | 284 |
| Neoplasms | D009369 | — | C80 | 148 | 76 | 21 | 1 | 13 | 229 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 60 | 121 | 46 | 2 | 17 | 225 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 40 | 85 | 71 | 1 | 28 | 212 |
| Esophageal neoplasms | D004938 | — | C15 | 26 | 109 | 47 | 5 | 19 | 185 |
| Urinary bladder neoplasms | D001749 | — | C67 | 30 | 97 | 27 | 2 | 11 | 152 |
| Small cell lung carcinoma | D055752 | — | — | 23 | 53 | 28 | 2 | 11 | 107 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 7 | 69 | 28 | 1 | 6 | 105 |
| Squamous cell carcinoma | D002294 | — | — | 28 | 58 | 18 | 1 | 4 | 97 |
Show 24 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 52 | 133 | 61 | — | 13 | 232 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 45 | 125 | 53 | — | 14 | 213 |
| Nasopharyngeal neoplasms | D009303 | — | — | 12 | 95 | 74 | — | 18 | 185 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 9 | 79 | 75 | — | 17 | 169 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 45 | 65 | 26 | — | 10 | 131 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 26 | 77 | 11 | — | 8 | 108 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 31 | 62 | 7 | — | 2 | 86 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 21 | 41 | 15 | — | 4 | 71 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 16 | 51 | 11 | — | 2 | 67 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 6 | 34 | 19 | — | 12 | 64 |
Show 119 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hearing loss | D034381 | EFO_0004238 | H91.9 | 2 | 5 | — | — | 4 | 10 |
| Uterine neoplasms | D014594 | EFO_0003859 | C55 | — | 5 | — | — | 2 | 7 |
| Thymus neoplasms | D013953 | — | C37 | 2 | 5 | — | — | — | 6 |
| Colonic neoplasms | D003110 | — | C18 | 3 | 4 | — | — | — | 6 |
| Penile neoplasms | D010412 | — | C60 | 1 | 5 | — | — | — | 6 |
| Brenner tumor | D001948 | — | — | 3 | 1 | — | — | 1 | 5 |
| Papillomaviridae | D027383 | — | — | — | 4 | — | — | 1 | 5 |
| B-cell lymphoma | D016393 | — | — | 4 | 2 | — | — | — | 5 |
| Cystadenocarcinoma | D003536 | — | — | 2 | 1 | — | — | 1 | 4 |
| Digestive system neoplasms | D004067 | — | — | 2 | 3 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Appendiceal neoplasms | D001063 | EFO_0003880 | C18.1 | 2 | — | — | — | 2 | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 3 | 4 |
| Rhabdomyosarcoma | D012208 | — | — | 2 | — | — | — | — | 2 |
| Desmoplastic small round cell tumor | D058405 | — | — | 2 | — | — | — | — | 2 |
| Hydronephrosis | D006869 | EFO_0005562 | N13.30 | 1 | — | — | — | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Pinealoma | D010871 | — | — | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Medical sociology | D012962 | — | — | 1 | — | — | — | — | 1 |
| Neurotoxicity syndromes | D020258 | — | G92 | 1 | — | — | — | — | 1 |
Show 3 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Circulating neoplastic cells | D009360 | — | — | — | — | — | — | 2 | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Cervical intraepithelial neoplasia | — | — | D06 | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 2 | 2 |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 1 | 1 |
| Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 1 | 1 |
| Dna damage | D004249 | — | — | — | — | — | — | 1 | 1 |
| Double-stranded dna breaks | D053903 | — | — | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Pleural effusion | D010996 | HP_0002202 | J90 | — | — | — | — | 1 | 1 |
Show 25 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Transplatin |
| INN | — |
| Description | trans-Dichlorodiammineplatinum(II) is the trans isomer of the coordination complex with the formula trans-PtCl2(NH3)2, sometimes called transplatin. It is a yellow solid with low solubility in water but good solubility in DMF. The existence of two isomers of PtCl2(NH3)2 led Alfred Werner to propose square planar molecular geometry. It belongs to the molecular symmetry point group D2h.
|
| Classification | Small molecule |
| Drug class | antineoplastics (platinum derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 15663-27-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1386 |
| ChEBI ID | 27899 |
| PubChem CID | 5702198 |
| DrugBank | DB00515 |
| UNII ID | — |
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Trends
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Safety
Black-box Warning
Black-box warning for: Cisplatin
Adverse Events
Top Adverse Reactions
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52,767 adverse events reported
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