Tranilast
Tranilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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Commercial
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Conjunctivitis | D003231 | HP_0000509 | H10 | — | — | — | 1 | — | 1 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | — | — | 1 | — | 1 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | 1 | — | 1 |
| Rosacea | D012393 | — | L71 | — | — | — | 1 | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperuricemia | D033461 | HP_0002149 | — | — | 3 | — | — | — | 3 |
| Gout | D006073 | EFO_0004274 | M10 | — | 3 | — | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 1 | — | — | — | 2 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | 1 | 1 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
| Cryopyrin-associated periodic syndromes | D056587 | — | M04.2 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | 1 | — | — | — | — | 1 |
| Scleredema adultorum | D012592 | — | — | 1 | — | — | — | — | 1 |
| Mucinoses | D017520 | — | — | 1 | — | — | — | — | 1 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Hypertrophy | D006984 | EFO_0002460 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tranilast |
| INN | tranilast |
| Description | Tranilast is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group. It has a role as an anti-asthmatic drug, a nephroprotective agent, an anti-allergic agent, a calcium channel blocker, an antineoplastic agent, an aryl hydrocarbon receptor agonist and a hepatoprotective agent. It is a member of cinnamamides, a dimethoxybenzene, an amidobenzoic acid and a secondary carboxamide. It is functionally related to an anthranilic acid. |
| Classification | Small molecule |
| Drug class | antiasthmatics/antiallergics (not acting primarily as antihistamines) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 53902-12-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL415324 |
| ChEBI ID | 77572 |
| PubChem CID | 5282230 |
| DrugBank | — |
| UNII ID | HVF50SMY6E (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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45 adverse events reported
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