Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 9 | 5 | 15 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | 1 | 1 | 2 |
Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | 1 | — | 2 |
Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | 1 | 1 | 2 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | 1 | — | 1 |
Left ventricular dysfunction | D018487 | — | — | — | — | — | 1 | — | 1 |
Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | 1 | — | 1 |
Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | 1 | — | 1 |
Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | 1 | — | 1 | 2 |
Pneumonia | D011014 | EFO_0003106 | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Essential hypertension | D000075222 | — | I10 | — | — | — | — | 1 | 1 |
Drug common name | Trandolapril |
INN | trandolapril |
Description | Trandolapril is a heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is a dicarboxylic acid monoester, a dipeptide, an ethyl ester, a secondary amino compound, a tertiary carboxamide and an organic heterobicyclic compound. It is functionally related to a trandolaprilat. |
Classification | Small molecule |
Drug class | antihypertensives (ACE inhibitors) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@H]2CCCC[C@@H]21 |
PDB | — |
CAS-ID | 87679-37-6 |
RxCUI | — |
ChEMBL ID | CHEMBL1519 |
ChEBI ID | — |
PubChem CID | 5484727 |
DrugBank | DB00519 |
UNII ID | 1T0N3G9CRC (ChemIDplus, GSRS) |