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AboutPricing
Drug ReportsTrandolapril
Trandolapril
Trandolapril (trandolapril) is a small molecule pharmaceutical. Trandolapril was first approved as Mavik on 1996-04-26. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
Trandolapril (discontinued: Mavik, Trandolapril)
Combinations
Trandolapril verapamil (discontinued: Tarka)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Trandolapril
Tradename
Company
Number
Date
Products
MAVIKAbbVieN-020528 DISCN1996-04-26
3 products, RLD
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Trandolapril
+
Verapamil hydrochloride
Tradename
Company
Number
Date
Products
TARKAAbbVieN-020591 DISCN1996-10-22
4 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
mavikNew Drug Application2012-02-14
tarkaNew Drug Application2012-02-13
trandolaprilANDA2024-05-30
trandolapril and verapamil hydrochlorideANDA2019-09-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
diabetic nephropathiesEFO_0000401D003928—
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
atrial fibrillationEFO_0000275D001281I48.0
myocardial infarctionEFO_0000612D009203I21
atrial flutterEFO_0003911D001282—
supraventricular tachycardia—D013617I47.1
variant angina pectoris—D000788I20.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA10: Trandolapril
— C09B: Ace inhibitors, combinations
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB10: Trandolapril and verapamil
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTrandolapril
INNtrandolapril
Description
Trandolapril is a heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension. It has a role as a prodrug, an antihypertensive agent and an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It is a dicarboxylic acid monoester, a dipeptide, an ethyl ester, a secondary amino compound, a tertiary carboxamide and an organic heterobicyclic compound. It is functionally related to a trandolaprilat.
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@H]2CCCC[C@@H]21
Identifiers
PDB—
CAS-ID87679-37-6
RxCUI—
ChEMBL IDCHEMBL1519
ChEBI ID—
PubChem CID5484727
DrugBankDB00519
UNII ID1T0N3G9CRC (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Trandolapril
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Refill frequency
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Price per prescription (USD)
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Trandolapril
+
Verapamil
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,571 documents
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Safety
Black-box Warning
Black-box warning for: Mavik, Tarka, Trandolapril, Trandolapril and verapamil hydrochloride
Adverse Events
Top Adverse Reactions
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1,883 adverse events reported
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