Brand Name | Status | Last Update |
---|---|---|
hycamtin | New Drug Application | 2023-09-18 |
topotecan | ANDA | 2024-02-15 |
topotecan hydrochloride | ANDA | 2024-10-04 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
ovarian neoplasms | EFO_0003893 | D010051 | C56 |
non-small-cell lung carcinoma | — | D002289 | — |
small cell carcinoma | — | D018288 | — |
uterine cervical neoplasms | — | D002583 | — |
small cell lung carcinoma | — | D055752 | — |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | 1 | — | — | 1 |
Fallopian tube neoplasms | D005185 | — | — | — | — | 1 | — | — | 1 |
Ovarian epithelial carcinoma | D000077216 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neuroblastoma | D009447 | EFO_0000621 | — | 1 | 1 | — | — | — | 2 |
Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
Medulloblastoma | D008527 | — | — | — | 1 | — | — | — | 1 |
Rhabdoid tumor | D018335 | — | — | — | 1 | — | — | — | 1 |
Ewing sarcoma | D012512 | EFO_0000173 | — | — | 1 | — | — | — | 1 |
Rhabdomyosarcoma | D012208 | — | — | — | 1 | — | — | — | 1 |
Diffuse intrinsic pontine glioma | D000080443 | — | — | — | 1 | — | — | — | 1 |
Drug common name | Topotecan |
INN | topotecan |
Description | Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent. ... More |
Classification | Small molecule |
Drug class | antineoplastics (camptothecin derivatives) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 |
PDB | — |
CAS-ID | 123948-87-8 |
RxCUI | — |
ChEMBL ID | CHEMBL84 |
ChEBI ID | 63632 |
PubChem CID | 60700 |
DrugBank | DB01030 |
UNII ID | 7M7YKX2N15 (ChemIDplus, GSRS) |