Tradename | Company | Number | Date | Products |
---|---|---|---|---|
EPRONTIA | Azurity | N-214679 RX | 2021-11-05 | 1 products, RLD, RS |
TOPAMAX | Johnson & Johnson | N-020505 RX | 1996-12-24 | 4 products, RLD |
TOPAMAX | Johnson & Johnson | N-020844 RX | 1998-10-26 | 2 products, RLD, RS |
TROKENDI XR | Supernus Pharmaceuticals | N-201635 RX | 2013-08-16 | 4 products, RLD, RS |
QUDEXY XR | Upsher-Smith Laboratories | N-205122 RX | 2014-03-11 | 5 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
eprontia | New Drug Application | 2025-03-21 |
phentermine and topiramate | ANDA | 2025-06-24 |
phentermine and topiramate extended-release | ANDA | 2025-05-21 |
qsymia | New Drug Application | 2024-10-03 |
qudexy | New Drug Application | 2025-02-07 |
qudexy qudexy | New Drug Application | 2025-03-03 |
qudexy qudexy | New Drug Application | 2025-04-10 |
topamax | New Drug Application | 2025-03-24 |
topiramate | ANDA | 2025-08-13 |
topiramate tablets | 2009-04-03 |
Expiration | Code | ||
---|---|---|---|
PHENTERMINE HYDROCHLORIDE / TOPIRAMATE, QSYMIA, VIVUS | |||
2025-06-24 | NPP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Topiramate, Eprontia, Azurity | |||
11433046 | 2040-08-21 | U-3413, U-3414, U-3415 | |
11633374 | 2040-08-21 | DP | |
Topiramate, Qudexy Xr, Upsher Smith Labs | |||
8652527 | 2033-03-19 | DP | |
8889190 | 2033-03-19 | DP | |
9101545 | 2033-03-19 | DP | |
9555005 | 2033-03-19 | DP | |
10363224 | 2033-03-19 | U-766 | |
Phentermine Hydrochloride / Topiramate, Qsymia, Vivus | |||
8580299 | 2029-06-14 | U-3399 | |
8580298 | 2029-05-15 | DP | |
8895057 | 2028-06-09 | U-3398 | |
8895058 | 2028-06-09 | DP | |
9011905 | 2028-06-09 | DP | |
9011906 | 2028-06-09 | U-3398 | |
Topiramate, Trokendi Xr, Supernus Pharms | |||
8298576 | 2028-04-04 | DP | U-106, U-1992 |
8298580 | 2027-11-16 | DP | U-106, U-1992 |
8663683 | 2027-11-16 | DP | U-106, U-1992 |
8877248 | 2027-11-16 | DP | U-106, U-1992 |
8889191 | 2027-11-16 | U-106, U-1992 | |
8992989 | 2027-11-16 | DP | U-1675, U-1992 |
9549940 | 2027-11-16 | DP | U-1675, U-1992 |
9555004 | 2027-11-16 | DP | U-1675, U-1992 |
9622983 | 2027-11-16 | DP | U-1675, U-1992 |
10314790 | 2027-11-16 | DP | U-1675, U-1992 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 2 | 4 | 3 | — | 11 |
Overweight | D050177 | — | E66.3 | — | 1 | — | 3 | — | 4 |
Pediatric obesity | D063766 | — | — | — | — | — | 2 | — | 2 |
Blood pressure | D001794 | EFO_0004325 | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | — | — | — | 2 |
Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | 1 | — | — | — | 1 |
Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | 1 | 1 | — | — | — | 1 |
Apnea | D001049 | — | R06.81 | 1 | 1 | — | — | — | 1 |
Bariatric surgery | D050110 | — | — | — | 1 | — | — | — | 1 |
Weight loss | D015431 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Torsades de pointes | D016171 | EFO_0005307 | I47.21 | 1 | — | — | — | — | 1 |
Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Topiramate |
INN | topiramate |
Description | Topiramate is a hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine. It has a role as an anticonvulsant and a sodium channel blocker. It is a cyclic ketal, a sulfamate ester and a ketohexose derivative. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |
PDB | — |
CAS-ID | 97240-79-4 |
RxCUI | — |
ChEMBL ID | CHEMBL220492 |
ChEBI ID | 63631 |
PubChem CID | 5284627 |
DrugBank | DB00273 |
UNII ID | 0H73WJJ391 (ChemIDplus, GSRS) |