Toludesvenlafaxine
Toludesvenlafaxine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
105 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 11 | 8 | 27 | 13 | 7 | 64 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 10 | 8 | 27 | 15 | 6 | 63 |
| Depression | D003863 | — | F33.9 | 5 | 9 | 27 | 13 | 4 | 55 |
| Hot flashes | D019584 | — | — | 2 | — | 3 | 1 | 2 | 8 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | — | 2 | 1 | — | 4 |
| Dysthymic disorder | D019263 | EFO_0008623 | F34.1 | — | 1 | — | 1 | 1 | 3 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | 2 | — | 3 |
| Pharmacokinetics | D010599 | — | — | — | — | — | 2 | — | 2 |
| Anhedonia | D059445 | — | R45.84 | — | — | — | 1 | 1 | 2 |
| Generalized anxiety disorder | D000098647 | — | — | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | 2 | 1 | — | 2 | 5 |
| Healthy volunteers/patients | — | — | — | 4 | — | 1 | — | — | 5 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | 3 | 4 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 1 | — | — | 2 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | — | 2 | — | — | 2 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | 1 | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | 1 | — | — | 1 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | — | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | — | R11.1 | — | — | — | — | 1 | 1 |
| Nausea | D009325 | — | R11.0 | — | — | — | — | 1 | 1 |
| Adjustment disorders | D000275 | — | F43.2 | — | — | — | — | 1 | 1 |
| Tension-type headache | D018781 | — | G44.2 | — | — | — | — | 1 | 1 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Toludesvenlafaxine |
| INN | toludesvenlafaxine |
| Description | Toludesvenlafaxine, also formerly known as ansofaxine and sold under the brand name Ruoxinlin, is an antidepressant which is approved for the treatment of major depressive disorder in China. It is also under development for use in other countries like the United States. It is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and was developed by Luye Pharma Group.
|
| Classification | Small molecule |
| Drug class | antianxiety, antidepressant inhibitor of norepinephrine and dopamine re-uptake |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(C(=O)Oc2ccc(C(CN(C)C)C3(O)CCCCC3)cc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 916918-84-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4227736 |
| ChEBI ID | — |
| PubChem CID | 56955395 |
| DrugBank | — |
| UNII ID | A7CGH459FN (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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