Tolterodine
Detrol, Tolterodine (tolterodine) is a small molecule pharmaceutical. Tolterodine was first approved as Detrol on 1998-03-25. It is used to treat urinary bladder diseases and urinary incontinence in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Detrol, Tolterodine (discontinued: Tolterodine)
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| detrol | New Drug Application | 2023-02-15 |
| detrol la | New Drug Application | 2023-03-15 |
| tolterodine tartarate tolterodine tartrate | ANDA | 2023-03-23 |
| tolterodine tartrate | ANDA | 2025-02-07 |
| tolterodine tartrate extended release | NDA authorized generic | 2024-12-14 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| urinary incontinence | — | D014549 | R32 |
| urinary bladder diseases | — | D001745 | N32.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
104 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 2 | — | — | 6 | 1 | 9 |
| Urinary incontinence | D014549 | — | R32 | — | — | 1 | 5 | — | 6 |
| Enuresis | D004775 | — | R32 | — | — | — | 2 | — | 2 |
| Memory | D008568 | — | — | — | — | — | 1 | — | 1 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | 1 | — | 1 |
| Urinary bladder neck obstruction | D001748 | EFO_1000840 | N32.0 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tolterodine |
| INN | tolterodine |
| Description | Tolterodine is a tertiary amine. It has a role as a muscarinic antagonist, a muscle relaxant and an antispasmodic drug. It is functionally related to a p-cresol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 124937-51-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1382 |
| ChEBI ID | 9622 |
| PubChem CID | 443879 |
| DrugBank | DB01036 |
| UNII ID | WHE7A56U7K (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Variants
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Financial
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Detrol – Pfizer
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Estimated US medical usage
Tolterodine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,879 adverse events reported
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