Tofogliflozin anhydrous
Tofogliflozin anhydrous is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | 2 | 1 | 4 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 2 | 1 | 3 |
| Diabetes complications | D048909 | — | — | — | — | — | 1 | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | — | 1 | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | 1 | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tofogliflozin anhydrous |
| INN | tofogliflozin |
| Description | Tofogliflozin (INN,: 88 USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi. It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of September 2012, the drug is in Phase III clinical trials.[needs update]
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| Classification | Small molecule |
| Drug class | phlorozin derivatives, phenolic glycosides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCc1ccc(Cc2ccc3c(c2)[C@]2(OC3)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 903565-83-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2110731 |
| ChEBI ID | — |
| PubChem CID | 46908928 |
| DrugBank | — |
| UNII ID | 554245W62T (ChemIDplus, GSRS) |
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Safety
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49 adverse events reported
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