Tirofiban
Aggrastat, Tirofiban (tirofiban) is a small molecule pharmaceutical. Tirofiban was first approved as Aggrastat on 1998-05-14. It is used to treat coronary disease, myocardial infarction, and unstable angina in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Aggrastat, Tirofiban (discontinued: Aggrastat)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aggrastat | New Drug Application | 2025-01-01 |
| tirofiban | ANDA | 2023-07-13 |
| tirofiban hydrochloride | ANDA | 2025-02-12 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myocardial infarction | EFO_0000612 | D009203 | I21 |
| coronary disease | — | D003327 | — |
| unstable angina | EFO_1000985 | D000789 | I20.0 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
| J3246 | Injection, tirofiban hcl, 0.25 mg |
Clinical
Clinical Trials
76 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 1 | 9 | 10 | 2 | 3 | 18 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 1 | 6 | 6 | 14 |
| St elevation myocardial infarction | D000072657 | — | — | — | — | 2 | 5 | 5 | 12 |
| Infarction | D007238 | EFO_0009463 | — | — | — | — | 3 | 9 | 12 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | 1 | 5 | 2 | 9 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | 1 | 5 | 2 | 1 | 9 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | 3 | 2 | 2 | 7 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | 1 | 5 | 1 | 7 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | 1 | 2 | 2 | 5 |
| Cerebral infarction | D002544 | — | I63 | — | 1 | 1 | 1 | 3 | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | — | 3 | — | 1 | 4 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | 1 | 1 | — | — | 2 |
| Thromboembolism | D013923 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 3 | — | — | 1 | 4 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | — | — | — | 1 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | 1 | — | — | — | 1 |
| Embolism and thrombosis | D016769 | — | — | — | 1 | — | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | — | — | — | 1 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | 1 | — | — | — | 1 |
| Stable angina | D060050 | — | I20.89 | — | 1 | — | — | — | 1 |
| Death | D003643 | PATO_0001422 | — | — | 1 | — | — | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombectomy | D017131 | — | — | — | — | — | — | 2 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 1 | 1 |
| Magnetic resonance imaging | D008279 | — | — | — | — | — | — | 1 | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 1 | 1 |
| Pathologic dilatation | D004108 | — | — | — | — | — | — | 1 | 1 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tirofiban |
| INN | tirofiban |
| Description | Tirofiban is a member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group. It has a role as a fibrin modulating drug, a platelet glycoprotein-IIb/IIIa receptor antagonist and an anticoagulant. It is a member of piperidines, a sulfonamide and a L-tyrosine derivative. |
| Classification | Small molecule |
| Drug class | fibrinogen receptor antagonists (glycoprotein IIb/IIIa receptor antagonists) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 144494-65-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL916 |
| ChEBI ID | 9605 |
| PubChem CID | 60947 |
| DrugBank | DB00775 |
| UNII ID | GGX234SI5H (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Aggrastat – SciClone Pharmaceuticals
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,894 adverse events reported
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