Tiratricol
Tiratricol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target thyroid hormone receptor alpha and thyroid hormone receptor beta.
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| childrens triacting nighttime | C200263 | 2023-10-13 |
| natural peeling triactive acne | OTC monograph final | 2016-11-01 |
| triacin-c | ANDA | 2015-07-28 |
| triacting daytime cold cough | C200263 | 2024-05-15 |
| vistogard | New Drug Application | 2025-02-07 |
| xuriden | New Drug Application | 2025-02-18 |
Indications
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FDA
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ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX08: Tiratricol
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H03: Thyroid therapy drugs
— H03A: Thyroid preparations
— H03AA: Thyroid hormones
— H03AA04: Tiratricol
HCPCS
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Clinical
Clinical Trials
166 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | 1 | — | 1 |
| Bronchitis | D001991 | — | J40 | — | — | — | 1 | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tiratricol |
| INN | tiratricol |
| Description | Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations.
|
| Classification | Small molecule |
| Drug class | Thyroid hormone |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 |
Identifiers
| PDB | — |
| CAS-ID | 51-24-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL41632 |
| ChEBI ID | — |
| PubChem CID | 5803 |
| DrugBank | DB03604 |
| UNII ID | 29OQ9EU4R1 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
THRA
THRA
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Variants
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Trends
PubMed Central
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Additional graphs summarizing 735 documents
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Safety
Black-box Warning
Black-box warning for: Triacin-c
Adverse Events
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77 adverse events reported
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