Tiratricol
Tiratricol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target thyroid hormone receptor alpha and thyroid hormone receptor beta.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| childrens triacting nighttime | C200263 | 2023-10-13 |
| natural peeling triactive acne | OTC monograph final | 2016-11-01 |
| triacin-c | ANDA | 2015-07-28 |
| triacting daytime cold cough | C200263 | 2024-05-15 |
| vistogard | New Drug Application | 2025-02-07 |
| xuriden | New Drug Application | 2025-02-18 |
Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AX: Other dermatological preparations in atc
— D11AX08: Tiratricol
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H03: Thyroid therapy drugs
— H03A: Thyroid preparations
— H03AA: Thyroid hormones
— H03AA04: Tiratricol
HCPCS
No data
Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 4 | 9 | 12 | 9 | 33 |
| Cough | D003371 | — | R05 | 2 | 3 | 4 | 5 | 5 | 19 |
| Helicobacter infections | D016481 | EFO_1000961 | — | — | 3 | 5 | 5 | 4 | 16 |
| Healthy volunteers/patients | — | — | — | 14 | — | — | 1 | — | 15 |
| Communicable diseases | D003141 | — | — | — | 1 | 8 | 2 | 1 | 11 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 3 | 3 | 4 | — | 9 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | 1 | 2 | 1 | 5 |
| Bronchitis | D001991 | — | J40 | — | — | 1 | 2 | 2 | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 1 | 3 | — | 4 |
| Common cold | D003139 | EFO_0007214 | J00 | — | 1 | 1 | 2 | — | 4 |
Show 33 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | 3 | — | — | 3 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | — | 3 | — | — | 3 |
| Ulcer | D014456 | MPATH_579 | — | — | — | 3 | — | — | 3 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | — | 2 | — | — | 2 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | 2 | — | — | 2 |
| Intestinal diseases | D007410 | — | K63.9 | — | — | 2 | — | — | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 2 | — | — | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | 1 | — | 1 | 2 |
| Hemophilia b | D002836 | — | D67 | — | — | 1 | — | 1 | 2 |
| Virus diseases | D014777 | — | B34 | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 1 | — | — | 3 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | 1 | 2 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 2 | — | — | — | 2 |
| Ataxia | D001259 | — | R27.0 | 1 | 2 | — | — | — | 2 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | 1 | 2 | — | — | — | 2 |
| Cerebellar ataxia | D002524 | — | — | 1 | 2 | — | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | 1 | 2 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | — | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Mucociliary clearance | D009079 | — | — | 1 | — | — | — | — | 1 |
| High-intensity focused ultrasound ablation | D057086 | — | — | 1 | — | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | — | 1 |
| Low-level light therapy | D028022 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | — | — | 2 | 2 |
| Whooping cough | D014917 | EFO_0000650 | A37 | — | — | — | — | 2 | 2 |
| Chronic cough | D000096822 | — | R05.3 | — | — | — | — | 2 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | — | — | 2 | 2 |
| Diarrhea | D003967 | — | R19.7 | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 1 | 1 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | — | — | — | — | 1 | 1 |
Show 35 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tiratricol |
| INN | tiratricol |
| Description | Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations.
|
| Classification | Small molecule |
| Drug class | Thyroid hormone |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 |
Identifiers
| PDB | — |
| CAS-ID | 51-24-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL41632 |
| ChEBI ID | — |
| PubChem CID | 5803 |
| DrugBank | DB03604 |
| UNII ID | 29OQ9EU4R1 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
THRA
THRA
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Triacin-c
Adverse Events
Top Adverse Reactions
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72 adverse events reported
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