Tipifarnib
Tipifarnib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against CHURC1-FNTB protein.
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Commercial
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Clinical
Clinical Trials
90 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 10 | 13 | 3 | — | 1 | 24 |
| Myeloid leukemia | D007951 | — | C92 | 8 | 11 | 3 | — | 1 | 20 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 6 | 11 | 3 | — | 1 | 19 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 6 | 7 | 1 | — | — | 12 |
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 7 | 2 | — | — | 11 |
| Syndrome | D013577 | — | — | 5 | 6 | 2 | — | — | 10 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 5 | 5 | 1 | — | — | 10 |
| Monocytic leukemia acute | D007948 | — | — | 5 | 5 | 1 | — | — | 10 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | 5 | 5 | 1 | — | — | 10 |
| Preleukemia | D011289 | — | — | 3 | 5 | 2 | — | — | 8 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 10 | — | — | — | 11 |
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 5 | — | — | — | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 3 | — | — | — | 6 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 3 | — | — | — | 5 |
| Plasma cell neoplasms | D054219 | — | — | 4 | 3 | — | — | — | 5 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | 4 | — | — | — | 5 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 4 | — | — | — | 5 |
| Glioma | D005910 | EFO_0000520 | — | 2 | 5 | — | — | — | 5 |
| Recurrence | D012008 | — | — | 2 | 3 | — | — | — | 4 |
| Basophilic leukemia acute | D015471 | — | C94.8 | 3 | 2 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 7 | — | — | — | — | 7 |
| Blast crisis | D001752 | — | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia chronic-phase | D015466 | — | — | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Insulinoma | D007340 | — | — | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tipifarnib |
| INN | tipifarnib |
| Description | Tipifarnib is a quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a quinolone, a member of monochlorobenzenes, a member of imidazoles and a primary amino compound. |
| Classification | Small molecule |
| Drug class | farnesyl transferase inhibitor |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C |
Identifiers
| PDB | — |
| CAS-ID | 192185-72-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL289228 |
| ChEBI ID | — |
| PubChem CID | 159324 |
| DrugBank | DB04960 |
| UNII ID | MAT637500A (ChemIDplus, GSRS) |
Target
Agency Approved
CHURC1-FNTB
CHURC1-FNTB
Alternate
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Variants
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Trends
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Safety
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Adverse Events
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81 adverse events reported
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