Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Leukemia | D007938 | — | C95 | 1 | 2 | 1 | — | — | 4 |
Myeloid leukemia | D007951 | — | C92 | 1 | 2 | 1 | — | — | 4 |
Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | 1 | — | — | 3 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 1 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
Preleukemia | D011289 | — | — | — | 1 | — | — | — | 1 |
Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
Myeloid leukemia chronic-phase | D015466 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Tipifarnib |
INN | tipifarnib |
Description | Tipifarnib is a quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a quinolone, a member of monochlorobenzenes, a member of imidazoles and a primary amino compound. |
Classification | Small molecule |
Drug class | farnesyl transferase inhibitor |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C |
PDB | — |
CAS-ID | 192185-72-1 |
RxCUI | — |
ChEMBL ID | CHEMBL289228 |
ChEBI ID | — |
PubChem CID | 159324 |
DrugBank | DB04960 |
UNII ID | MAT637500A (ChemIDplus, GSRS) |