Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Leukemia | D007938 | — | C95 | 10 | 13 | 3 | — | 1 | 24 |
Myeloid leukemia | D007951 | — | C92 | 8 | 11 | 3 | — | 1 | 20 |
Myeloid leukemia acute | D015470 | — | C92.0 | 6 | 11 | 3 | — | 1 | 19 |
Myelomonocytic leukemia acute | D015479 | — | C92.5 | 6 | 7 | 1 | — | — | 12 |
Myelodysplastic syndromes | D009190 | — | D46 | 4 | 7 | 2 | — | — | 11 |
Syndrome | D013577 | — | — | 5 | 6 | 2 | — | — | 10 |
Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 5 | 5 | 1 | — | — | 10 |
Monocytic leukemia acute | D007948 | — | — | 5 | 5 | 1 | — | — | 10 |
Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | 5 | 5 | 1 | — | — | 10 |
Preleukemia | D011289 | — | — | 3 | 5 | 2 | — | — | 8 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 10 | — | — | — | 11 |
Neoplasms | D009369 | — | C80 | 7 | 1 | — | — | — | 8 |
Glioblastoma | D005909 | EFO_0000515 | — | 4 | 5 | — | — | — | 7 |
Non-small-cell lung carcinoma | D002289 | — | — | 3 | 3 | — | — | — | 6 |
Multiple myeloma | D009101 | — | C90.0 | 4 | 3 | — | — | — | 5 |
Plasma cell neoplasms | D054219 | — | — | 4 | 3 | — | — | — | 5 |
Recurrence | D012008 | — | — | 2 | 4 | — | — | — | 5 |
Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | 4 | — | — | — | 5 |
Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 4 | — | — | — | 5 |
Glioma | D005910 | EFO_0000520 | — | 2 | 5 | — | — | — | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Blast crisis | D001752 | — | — | 1 | — | — | — | — | 1 |
Myeloid leukemia chronic-phase | D015466 | — | — | 1 | — | — | — | — | 1 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
Insulinoma | D007340 | — | — | 1 | — | — | — | — | 1 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
Anus neoplasms | D001005 | EFO_0003835 | C21 | 1 | — | — | — | — | 1 |
Drug common name | Tipifarnib |
INN | tipifarnib |
Description | Tipifarnib is a quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a quinolone, a member of monochlorobenzenes, a member of imidazoles and a primary amino compound. |
Classification | Small molecule |
Drug class | farnesyl transferase inhibitor |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C |
PDB | — |
CAS-ID | 192185-72-1 |
RxCUI | — |
ChEMBL ID | CHEMBL289228 |
ChEBI ID | — |
PubChem CID | 159324 |
DrugBank | DB04960 |
UNII ID | MAT637500A (ChemIDplus, GSRS) |