Tipifarnib
Tipifarnib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against CHURC1-FNTB protein.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
No data
Clinical
Clinical Trials
90 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 11 | 14 | 3 | — | 1 | 26 |
| Myeloid leukemia | D007951 | — | C92 | 9 | 11 | 3 | — | 1 | 21 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 6 | 11 | 3 | — | 1 | 19 |
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 7 | 2 | — | — | 11 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 5 | 7 | 1 | — | — | 11 |
| Syndrome | D013577 | — | — | 5 | 6 | 2 | — | — | 10 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 4 | 5 | 1 | — | — | 9 |
| Monocytic leukemia acute | D007948 | — | — | 4 | 5 | 1 | — | — | 9 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | 4 | 5 | 1 | — | — | 9 |
| Preleukemia | D011289 | — | — | 3 | 5 | 2 | — | — | 8 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 10 | — | — | — | 10 |
| Neoplasms | D009369 | — | C80 | 7 | 2 | — | — | — | 9 |
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 5 | — | — | — | 7 |
| Recurrence | D012008 | — | — | 2 | 5 | — | — | — | 6 |
| Lymphoma | D008223 | — | C85.9 | 1 | 5 | — | — | — | 6 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 3 | — | — | — | 5 |
| Plasma cell neoplasms | D054219 | — | — | 4 | 3 | — | — | — | 5 |
| Carcinoma | D002277 | — | C80.0 | 2 | 5 | — | — | — | 5 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 3 | 4 | — | — | — | 5 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 3 | 4 | — | — | — | 5 |
Show 81 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blast crisis | D001752 | — | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia chronic-phase | D015466 | — | — | 1 | — | — | — | — | 1 |
| Plasmacytoma | D010954 | — | C90.3 | 1 | — | — | — | — | 1 |
| Cytopenia | D000095542 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Tipifarnib |
| INN | tipifarnib |
| Description | Tipifarnib is a quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a quinolone, a member of monochlorobenzenes, a member of imidazoles and a primary amino compound. |
| Classification | Small molecule |
| Drug class | farnesyl transferase inhibitor |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2c(c1)c(-c1cccc(Cl)c1)cc(=O)n2C |
Identifiers
| PDB | — |
| CAS-ID | 192185-72-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL289228 |
| ChEBI ID | — |
| PubChem CID | 159324 |
| DrugBank | DB04960 |
| UNII ID | MAT637500A (ChemIDplus, GSRS) |
Target
Agency Approved
CHURC1-FNTB
CHURC1-FNTB
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 2,732 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
80 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use