Tioconazole
Tioconazole, Vagistat (tioconazole) is a small molecule pharmaceutical. Tioconazole was first approved as Tz-3 on 1983-02-18. It is used to treat mycoses and vulvovaginal candidiasis in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Tioconazole, Vagistat (discontinued: Tz)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| basic care tioconazole | ANDA | 2024-12-18 |
| careone tioconazole 1 | ANDA | 2024-12-18 |
| dg health tioconazole 1 | ANDA | 2021-05-11 |
| equaline tioconazole 1 | ANDA | 2023-07-24 |
| equate tioconazole 1 day | ANDA | 2025-08-11 |
| foster and thrive tioconazole | ANDA | 2023-10-25 |
| good sense tioconazole 1 | ANDA | 2023-12-19 |
| leader ticonazole | ANDA | 2021-06-23 |
| leader tioconazole 1 | ANDA | 2025-02-19 |
| monistat tioconazole 1 | ANDA | 2019-03-19 |
Show 9 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| mycoses | — | D009181 | B35-B49 |
| vulvovaginal candidiasis | EFO_0007543 | D002181 | B37.3 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC07: Tioconazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF08: Tioconazole
HCPCS
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Clinical
Clinical Trials
156 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Candidiasis | D002177 | — | B37 | 1 | 7 | 10 | 9 | 5 | 29 |
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | 1 | 5 | 6 | 7 | 5 | 20 |
| Mycoses | D009181 | — | B35-B49 | 3 | 3 | 5 | 1 | 3 | 14 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | 1 | 1 | 4 | 3 | 1 | 10 |
| Tinea | D014005 | EFO_0007510 | B35.4 | 5 | 1 | 2 | 1 | 1 | 10 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 4 | 1 | 4 | 10 |
| Vaginitis | D014627 | EFO_0005757 | N76 | — | 1 | 4 | 2 | 1 | 7 |
| Oral lichen planus | D017676 | — | — | 1 | 1 | — | 3 | 2 | 7 |
| Lichen planus | D008010 | — | L43 | 1 | 1 | — | 3 | 2 | 7 |
| Tinea pedis | D014008 | EFO_0007512 | B35.3 | 4 | — | 2 | 1 | — | 7 |
Show 23 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Otomycosis | D059249 | — | — | 1 | 2 | 3 | — | 3 | 8 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | 1 | 5 | 1 | — | — | 7 |
| Communicable diseases | D003141 | — | — | — | 1 | 3 | — | 2 | 6 |
| Invasive fungal infections | D000072742 | — | — | 1 | 1 | 1 | — | 2 | 5 |
| Aspergillosis | D001228 | EFO_0007157 | B44 | — | 3 | 1 | — | 1 | 5 |
| Tinea cruris | D000084002 | — | B35.6 | 1 | 1 | 1 | — | — | 3 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 2 | — | 1 | 3 |
| Corneal ulcer | D003320 | — | H16.0 | — | — | 1 | — | 1 | 2 |
| Keratitis | D007634 | — | H16 | — | — | 1 | — | 1 | 2 |
| Ulcer | D014456 | MPATH_579 | — | 1 | — | 1 | — | — | 2 |
Show 16 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 5 | 4 | — | — | — | 7 |
| Mucositis | D052016 | EFO_1001898 | — | 1 | 3 | — | — | 1 | 5 |
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | — | 4 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | — | 3 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | 1 | — | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | — | — | 1 | 2 |
| Hematologic neoplasms | D019337 | — | — | — | 1 | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | 1 | 2 |
| Multiple myeloma | D009101 | — | C90.0 | — | 2 | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 2 | — | — | — | 2 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 2 | — | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | 1 | 2 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | 1 | 2 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | — | — | 1 |
| Wound infection | D014946 | — | — | 1 | — | — | — | — | 1 |
| Foot ulcer | D016523 | — | — | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine cervical dysplasia | D002578 | EFO_1000910 | N87 | — | — | — | — | 2 | 2 |
| Tachycardia | D013610 | — | R00.0 | — | — | — | — | 2 | 2 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 2 | 2 |
| Uterine cervical neoplasms | D002583 | — | — | — | — | — | — | 2 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | — | 1 | 1 |
| Acute-on-chronic liver failure | D065290 | — | — | — | — | — | — | 1 | 1 |
| Laser therapy | D053685 | — | — | — | — | — | — | 1 | 1 |
| Uterine cervical diseases | D002577 | — | — | — | — | — | — | 1 | 1 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
Show 27 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tioconazole |
| INN | tioconazole |
| Description | 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2. It is an ether, a member of imidazoles, a member of thiophenes and a dichlorobenzene. |
| Classification | Small molecule |
| Drug class | systemic antifungals (miconazole type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1 |
Identifiers
| PDB | — |
| CAS-ID | 65899-73-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200438 |
| ChEBI ID | 77898 |
| PubChem CID | 5482 |
| DrugBank | DB01007 |
| UNII ID | S57Y5X1117 (ChemIDplus, GSRS) |
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Tioconazole
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Safety
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Adverse Events
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2,298 adverse events reported
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