Tradename | Company | Number | Date | Products |
---|---|---|---|---|
COSOPT | Thea Pharma | N-020869 RX | 1998-04-07 | 1 products, RLD, RS |
COSOPT PF | Thea Pharma | N-202667 RX | 2012-02-01 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TIMOLIDE 10-25 | Merck KGaA | N-018061 DISCN | 1982-01-01 | 1 products |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
BETIMOL | Thea Pharma | N-020439 RX | 1995-03-31 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ISTALOL | Bausch Health Companies | N-021516 RX | 2004-06-04 | 1 products, RLD, RS |
TIMOPTIC | Bausch Health Companies | N-018086 RX | 1982-01-01 | 2 products, RLD |
TIMOPTIC IN OCUDOSE | Bausch Health Companies | N-019463 RX | 1986-11-05 | 2 products, RLD, RS |
TIMOPTIC-XE | Bausch Health Companies | N-020330 RX | 1993-11-04 | 2 products, RLD |
TIMOLOL MALEATE | Sandoz | N-020963 RX | 1998-10-21 | 2 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
brimonidine tartrate and timolol maleate | ANDA | 2023-10-31 |
brimonidine tartrate/timolol maleate | ANDA | 2023-11-03 |
brimonidine tartrate/timolol maleate ophthalmic solution | ANDA | 2023-12-01 |
combigan | New Drug Application | 2019-06-27 |
cosopt | New Drug Application | 2023-09-05 |
cosopt pf | New Drug Application | 2024-01-08 |
dorzolamide and timolol | ANDA | 2019-11-15 |
dorzolamide hcl /timolol maleate | ANDA | 2013-01-29 |
dorzolamide hcl and timolol maleate | ANDA | 2018-02-13 |
dorzolamide hydrochloride and timolol maleate | ANDA | 2024-01-26 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ocular hypertension | D009798 | EFO_1001069 | H40.0 | 8 | 25 | 69 | 46 | 23 | 165 |
Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | 6 | 22 | 49 | 41 | 22 | 134 |
Glaucoma | D005901 | EFO_0000516 | H40 | 7 | 6 | 24 | 51 | 14 | 101 |
Healthy volunteers/patients | — | — | — | 2 | 1 | 1 | 1 | — | 5 |
Low tension glaucoma | D057066 | EFO_1001022 | H40.12 | — | 1 | — | 3 | 1 | 5 |
Exfoliation syndrome | D017889 | EFO_0004235 | — | — | — | 1 | 1 | 2 | 4 |
Macular edema | D008269 | — | — | — | 2 | 1 | 1 | — | 3 |
Eye diseases | D005128 | EFO_0003966 | H44 | 1 | — | — | 2 | — | 3 |
Anterior uveitis | D014606 | EFO_1000811 | — | — | — | — | 1 | — | 1 |
Angle-closure glaucoma | D015812 | — | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hemangioma | D006391 | — | D18.0 | 1 | 2 | 1 | — | 1 | 5 |
Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 2 | 1 | — | — | 2 |
Wet macular degeneration | D057135 | EFO_0004683 | — | — | 2 | 1 | — | — | 2 |
Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | 2 | — | — | 2 |
Surgical wound | D000072836 | — | — | — | 2 | 2 | — | — | 2 |
Paronychia | D010304 | EFO_0007421 | L03.0 | — | — | 1 | — | 1 | 2 |
Gastrointestinal hemorrhage | D006471 | HP_0002239 | K92.2 | — | — | 1 | — | — | 1 |
Visual acuity | D014792 | — | — | — | — | 1 | — | — | 1 |
Corneal edema | D015715 | EFO_1000879 | H18.20 | — | — | 1 | — | — | 1 |
Diabetic foot | D017719 | EFO_1001459 | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hereditary hemorrhagic telangiectasia | D013683 | — | I78.0 | 1 | 3 | — | — | — | 3 |
Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | 1 | 2 |
Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | 1 | — | — | — | 1 |
Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | — | 1 |
Burns | D002056 | — | T30.0 | — | 1 | — | — | — | 1 |
Cataract | D002386 | HP_0000518 | H26.9 | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acne vulgaris | D000152 | EFO_0003894 | L70 | 1 | — | — | — | 1 | 2 |
Rosacea | D012393 | — | L71 | 1 | — | — | — | — | 1 |
Ischemic optic neuropathy | D018917 | EFO_1000809 | H47.01 | 1 | — | — | — | — | 1 |
Sturge-weber syndrome | D013341 | Orphanet_3205 | Q85.89 | 1 | — | — | — | — | 1 |
Port-wine stain | D019339 | — | Q82.5 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
Diabetes complications | D048909 | — | — | — | — | — | — | 1 | 1 |
Ocular physiological phenomena | D009799 | — | — | — | — | — | — | 1 | 1 |
Scleral buckling | D012591 | — | — | — | — | — | — | 1 | 1 |
Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 1 | 1 |
Retinal perforations | D012167 | EFO_1001028 | — | — | — | — | — | 1 | 1 |
Drug common name | Timolol |
INN | timolol |
Description | (S)-timolol (anhydrous) is the (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine. It has a role as an antiglaucoma drug, an antihypertensive agent, an anti-arrhythmia drug and a beta-adrenergic antagonist. It is a conjugate base of a (S)-timolol(1+). It is an enantiomer of a (R)-timolol. |
Classification | Small molecule |
Drug class | beta-blockers (propranolol type) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1 |
PDB | — |
CAS-ID | 26839-75-8 |
RxCUI | — |
ChEMBL ID | CHEMBL499 |
ChEBI ID | 9599 |
PubChem CID | 33624 |
DrugBank | DB00373 |
UNII ID | 5JKY92S7BR (ChemIDplus, GSRS) |