Tygacil(tigecycline)
Tigecycline, Tygacil (tigecycline) is a small molecule pharmaceutical. Tigecycline was first approved as Tygacil on 2005-06-15. It is used to treat bacteremia, bacterial infections, bacterial pneumonia, bacterial skin diseases, and bacteroides infections amongst others in the USA. It has been approved in Europe to treat bacterial infections, bacterial skin diseases, infectious skin diseases, intraabdominal infections, and soft tissue infections.
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Tigecycline, Tygacil (discontinued: Tigecycline)
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tigecycline
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TIGECYCLINE | Amneal Pharmaceuticals | N-211158 RX | 2018-08-02 | 1 products |
| TIGECYCLINE | Fresenius Kabi | N-205645 RX | 2016-12-01 | 1 products, RLD, RS |
| TYGACIL | CV Sciences | N-021821 RX | 2005-06-15 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tigecycline | ANDA | 2024-10-01 |
| tygacil | New Drug Application | 2023-04-20 |
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Drug
General
| Drug common name | Tigecycline |
| INN | tigecycline |
| Description | Tigecycline, sold under the brand name Tygacil, is a tetracycline antibiotic medication for a number of bacterial infections. It is a glycylcycline administered intravenously. It was developed in response to the growing rate of antibiotic resistant bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include Gram-positive and Gram-negative organisms, including those of multi-drug resistance.
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| Classification | Small molecule |
| Drug class | antibiotics (tetracycline derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)c1cc(NC(=O)CNC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O |
Identifiers
| PDB | — |
| CAS-ID | 220620-09-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL376140 |
| ChEBI ID | 149836 |
| PubChem CID | 5282044 |
| DrugBank | DB00560 |
| UNII ID | 70JE2N95KR (ChemIDplus, GSRS) |
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Tygacil – Pfizer
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Black-box Warning
Black-box warning for: Tigecycline, Tygacil
Adverse Events
0 adverse events reported
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