Ticlopidine - PharmaKB

Ticlopidine

Ticlid (ticlopidine) is a small molecule pharmaceutical. Ticlopidine was first approved as Ticlid on 1991-10-31. It is used to treat intracranial embolism and thrombosis in the USA. It is known to target cytochrome P450 2B6.

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Events

FDA approval date

EMA approval date

Patent expiration date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
nervous system diseases	D009422
cardiovascular diseases	D002318

Trade Name

FDA

EMA

No data

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Ticlopidine hydrochloride

Tradename	Company	Number	Date	Products
TICLID	Roche	N-019979 DISCN	1991-10-31	2 products

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FDA

EMA

Brand Name	Status	Last Update
ticlopidine hydrochloride	ANDA	2016-08-06

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
intracranial embolism and thrombosis	—	D002542	—

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

B: Blood and blood forming organ drugs

— B01: Antithrombotic agents

— B01A: Antithrombotic agents

— B01AC: Platelet aggregation inhibitors excl. heparin

— B01AC05: Ticlopidine

HCPCS

Code	Description
G9531	Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar

Clinical

Clinical Trials

719 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Coronary artery disease	D003324	—	I25.1	7	19	28	106	22	176
Acute coronary syndrome	D054058	EFO_0005672	—	8	12	28	45	16	107
Myocardial infarction	D009203	EFO_0000612	I21	—	5	18	38	7	66
Coronary disease	D003327	—	—	—	7	6	39	9	58
Ischemic stroke	D000083242	—	—	2	7	23	17	12	57
Stroke	D020521	EFO_0000712	I63.9	—	8	24	17	11	55
Myocardial ischemia	D017202	EFO_1001375	I20-I25	—	7	6	36	7	54
Healthy volunteers/patients	—	—	—	40	1	—	4	2	47
Thrombosis	D013927	—	—	2	4	10	12	7	35
Percutaneous coronary intervention	D062645	—	—	1	5	8	15	8	35

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Cognitive dysfunction	D060825	—	G31.84	—	2	1	—	2	4
Intracranial hemorrhages	D020300	EFO_0000551	I62	—	—	1	—	2	3
Chronic obstructive pulmonary disease	D029424	EFO_0000341	J44.9	—	2	1	—	—	3
Thromboembolism	D013923	—	—	—	2	1	—	1	3
Congenital heart defects	D006330	—	Q24.9	—	1	2	—	—	3
Pneumonia	D011014	EFO_0003106	J18	—	1	1	—	—	2
Cerebral hemorrhage	D002543	—	—	—	1	1	—	—	2
Recurrence	D012008	—	—	—	1	2	—	—	2
Heart valve diseases	D006349	EFO_0009551	I08	—	—	1	—	1	2
Coronary artery bypass	D001026	EFO_0003776	—	—	—	2	—	—	2

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Head and neck neoplasms	D006258	—	—	1	1	—	—	—	2
Hiv	D006678	—	O98.7	1	1	—	—	—	2
Blood platelet disorders	D001791	—	—	—	1	—	—	1	2
Coronavirus infections	D018352	EFO_0007224	B34.2	—	1	—	—	—	1
Respiratory insufficiency	D012131	—	J96.9	—	1	—	—	—	1
Viral pneumonia	D011024	EFO_0007541	J12.9	—	1	—	—	—	1
Cognition disorders	D003072	—	—	—	1	—	—	—	1
Hiv infections	D015658	EFO_0000764	B20	—	1	—	—	—	1
Lung diseases	D008171	EFO_0003818	J98.4	—	1	—	—	—	1
Obstructive lung diseases	D008173	—	—	—	1	—	—	—	1

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Therapeutic equivalency	D013810	—	—	2	—	—	—	—	2
Fasting	D005215	EFO_0002756	—	2	—	—	—	—	2
Hemostasis	D006487	—	—	2	—	—	—	—	2
Depressive disorder	D003866	EFO_1002014	F32.A	1	—	—	—	1	2
Acquired immunodeficiency syndrome	D000163	EFO_0000765	B20	1	—	—	—	—	1
Crush injuries	D000071576	—	T14.8	1	—	—	—	—	1
Major depressive disorder	D003865	EFO_0003761	F22	1	—	—	—	—	1
Hemolytic anemia	D000743	—	D55-D59	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pulmonary embolism	D011655	EFO_0003827	I26	—	—	—	—	4	4
Hip fractures	D006620	EFO_0003964	S72.00	—	—	—	—	2	2
Asymptomatic diseases	D058070	—	—	—	—	—	—	2	2
Cerebrovascular disorders	D002561	EFO_0003763	I60-I69	—	—	—	—	2	2
Coronary occlusion	D054059	—	I21	—	—	—	—	1	1
Cerebral amyloid angiopathy	D016657	EFO_0006790	I68.0	—	—	—	—	1	1
Familial cerebral amyloid angiopathy	D028243	—	—	—	—	—	—	1	1
Surgical blood loss	D016063	—	—	—	—	—	—	1	1
Hyperuricemia	D033461	—	—	—	—	—	—	1	1
Leg ulcer	D007871	—	—	—	—	—	—	1	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Ticlopidine
INN	ticlopidine
Description	Ticlopidine is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group. It has a role as a fibrin modulating drug, a hematologic agent, an anticoagulant, a platelet aggregation inhibitor and a P2Y12 receptor antagonist. It is a thienopyridine and a member of monochlorobenzenes.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	Clc1ccccc1CN1CCc2sccc2C1