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Drug ReportsThrombin
Thrombin
Evicel, TachoSil, VeraSeal (thrombin) is an unknown pharmaceutical. Thrombin was first approved as Tachosil on 2004-06-08. It is used to treat hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis.
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Drug
Target
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Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
therapeuticsD013812
operative surgical proceduresD013514
circulatory and respiratory physiological phenomenaD002943
Trade Name
FDA
EMA
Evithrom, Recothrom, Thrombin-jmi, thrombocoll (discontinued: Evithrom)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Thrombin
+
topical (bovine)
Tradename
Proper name
Company
Number
Date
Products
Thrombin-Jmi, ThrombocollThrombin, Topical (Bovine)GenTracA-102865 RX1986-02-03
2 products
Thrombin
+
topical (human)
Tradename
Proper name
Company
Number
Date
Products
EvithromThrombin, Topical (Human)Omrix BiopharmaceuticalsA-125247 RX2009-09-17
1 products
Show 1 discontinued
Thrombin topical (recombinant)
Tradename
Proper name
Company
Number
Date
Products
RecothromThrombin topical (Recombinant)BaxterA-125248 RX2008-01-17
2 products
Labels
FDA
EMA
Brand Name
Status
Last Update
recothromBiologic Licensing Application2025-06-09
tachosilBiologic Licensing Application2025-02-11
thrombin humanBiologic Licensing Application2009-09-13
thrombin-jmiBiologic Licensing Application2011-06-17
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hemorrhageMP_0001914D006470R58
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AE: Direct thrombin inhibitors
— B02: Antihemorrhagics
— B02B: Vitamin k and other hemostatics
— B02BC: Local hemostatics
— B02BC06: Thrombin
— B02BD: Blood coagulation factors
— B02BD30: Thrombin
HCPCS
Code
Description
J7168
Prothrombin complex concentrate (human), kcentra, per i.u. of factor ix activity
J7196
Injection, antithrombin recombinant, 50 i.u.
J7197
Antithrombin iii (human), per i.u.
Clinical
Clinical Trials
565 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Surgical blood lossD016063————1——1
HemorrhageD006470MP_0001914R58——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemostasisD006487———1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameThrombin
INNthrombin
Description
Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
Classification
Unknown
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>4UD9:H|Thrombin heavy chain IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE >4UD9:I|Hirudin-2 GDFEEIPEE(TYS)LQ >4UD9:L|Prothrombin EADCGLRPLFEKKSLEDKTERELLESYI
Identifiers
PDB148D, 1A0H, 1A2C, 1A3B, 1A3E, 1A46, 1A4W, 1A5G, 1A61, 1ABI, 1ABJ, 1AD8, 1AE8, 1AFE, 1AHT, 1AI8, 1AIX, 1AVG, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BBR, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DLK, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DWE, 1DX5, 1E0F, 1EB1, 1EGT, 1EOJ, 1EOL, 1ETR, 1ETS, 1ETT, 1FPC, 1FPH, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAG, 1HAH, 1HAI, 1HAO, 1HAP, 1HBT, 1HDT, 1HGT, 1HLT, 1HRT, 1HUT, 1HXE, 1HXF, 1ID5, 1IHS, 1IHT, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KMA, 1KTS, 1KTT, 1KWM, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MKW, 1MKX, 1MU6, 1MU8, 1MUE, 1NM6, 1NO9, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1OOK, 1OYT, 1P8V, 1PPB, 1PPC, 1PPH, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RDE, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1TBQ, 1TBR, 1TBZ, 1THP, 1THR, 1THS, 1TMB, 1TMT, 1TMU, 1TOC, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UCY, 1UMA, 1UVS, 1UVT, 1UVU, 1VIT, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YCP, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A1D, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8W, 2C8X, 2C8Y, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2ERW, 2F3C, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2IDN, 2JH0, 2JH5, 2JH6, 2OCV, 2OD3, 2ODY, 2PGB, 2PGQ, 2PKS, 2PUX, 2PV9, 2PW8, 2R2M, 2THF, 2UUF, 2UUJ, 2UUK, 2UWL, 2UWO, 2V3H, 2V3O, 2WV1, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZFQ, 2ZFR, 2ZG0, 2ZGB, 2ZGX, 2ZHE, 2ZHF, 2ZHQ, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 2ZPK, 3A1M, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3D4U, 3D66, 3D67, 3D68, 3DA9, 3DD2, 3DGV, 3DHK, 3DT0, 3DUX, 3EDX, 3EE0, 3EGK, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HK3, 3HK6, 3HKI, 3HKJ, 3HTC, 3JZ1, 3JZ2, 3K65, 3LDX, 3LMS, 3LU9, 3OSL, 3P17, 3P6Z, 3P70, 3PMA, 3PMB, 3PMH, 3PO1, 3QDZ, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S69, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VW7, 3VXE, 3VXF, 4AX9, 4AYV, 4AYY, 4AZ2, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4BTI, 4BTT, 4BTU, 4CH2, 4CH8, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7N, 4E7R, 4GSO, 4H6S, 4H6T, 4HFP, 4HTC, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4P10, 4RKJ, 4RKO, 4RN6, 4THN, 4UD9, 4UDW, 4UE7, 4UEH, 4UFD, 4UFE, 4UFF, 4UFG, 4YES, 5A2M, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 5DO4, 5E8E, 5EW1, 5EW2, 5GDS, 5GIM, 5HVF, 5HVG, 5HVH, 5JDU, 5JFD, 5JQN, 5JZY, 5L6N, 5LCE, 5LPD, 5MJT, 5MLS, 5MM6, 5NDD, 5NDZ, 5NHU, 5NJ6, 5TO3, 5XRF, 6CYM, 6EO6, 6EO7, 6EO8, 6EO9, 6EVV, 6FJT, 6GBW, 6GN7, 6GWE, 6HSX, 6I51, 6P9U, 6PXJ, 6PXQ, 6ROT, 6T3M, 6T3Q, 6T4A, 6T52, 6T53, 6T54, 6T55, 6T56, 6T57, 6T7H, 6T89, 6T8A, 6TDT, 6TFI, 6TKG, 6TKH, 6TKI, 6TKJ, 6TKL, 6V64, 6Y02, 6Y9H, 6YB6, 6YHG, 6YHJ, 6YMP, 6YN3, 6YQV, 6YSJ, 6YSX, 6Z48, 6Z8V, 6Z8W, 6Z8X, 6ZGO, 6ZUG, 6ZUH, 6ZUN, 6ZUU, 6ZUW, 6ZUX, 6ZV7, 6ZV8, 7A0D, 7A0E, 7A0F, 7AC9, 7KME, 7MJ5, 7NEE, 7NEU, 7NTU, 7PHX, 7SR9, 7V3T, 7ZKL, 7ZKM, 7ZKN, 7ZKO, 8ASE, 8ASF, 8BW5, 8BWW, 8EF4, 8KME
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL2108110
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID25ADE2236L (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Recothrom – Bristol Myers Squibb
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,099 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,065 adverse events reported
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