Thioridazine
Mellaril-s, Thioridazine (thioridazine) is a small molecule pharmaceutical. Thioridazine was first approved as Mellaril-s on 1982-01-01. It is used to treat psychotic disorders and schizophrenia in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A. In addition, it is known to target G protein-activated inward rectifier potassium channel 2, D(1A) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 1A, histamine H1 receptor, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 6.
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Events
FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Thioridazine (discontinued: Mellaril, Mellaril-s, Thioridazine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| thioridazine hcl | 2006-11-27 | |
| thioridazine hydrochloride | ANDA | 2024-09-15 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| schizophrenia | EFO_0000692 | D012559 | F20 |
| psychotic disorders | — | D011618 | F20.81 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 2 | 3 | 6 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | 1 | 2 | 3 |
| Schizophrenia spectrum and other psychotic disorders | D019967 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | — | 1 | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | 1 | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
| Body weight | D001835 | EFO_0004338 | — | 1 | — | — | — | — | 1 |
| Weight gain | D015430 | HP_0004324 | — | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Tick-borne encephalitis | D004675 | EFO_1001309 | A84 | 1 | — | — | — | — | 1 |
| Encephalitis | D004660 | HP_0002383 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 2 | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Emergencies | D004630 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Thioridazine |
| INN | thioridazine |
| Description | Thioridazine is a phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. It has a role as a serotonergic antagonist, a H1-receptor antagonist, an alpha-adrenergic antagonist, a dopaminergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor. It is a member of phenothiazines and a member of piperidines. It contains a methylsulfanyl group. |
| Classification | Small molecule |
| Drug class | Typical antipsychotic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 |
Identifiers
| PDB | — |
| CAS-ID | 50-52-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL479 |
| ChEBI ID | 9566 |
| PubChem CID | 5452 |
| DrugBank | DB00679 |
| UNII ID | N3D6TG58NI (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
MALT1
MALT1
Organism
Homo sapiens
Gene name
MALT1
Gene synonyms
MLT
NCBI Gene ID
Protein name
mucosa-associated lymphoid tissue lymphoma translocation protein 1
Protein synonyms
caspase-like protein, MALT lymphoma-associated translocation, MALT1 protease, mucosa associated lymphoid tissue lymphoma translocation gene 1, Paracaspase, paracaspase-1
Uniprot ID
Mouse ortholog
Malt1 (240354)
mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (Q8C7N9)
Variants
No data
Financial
Revenue by drug
$
€
£
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Estimated US medical usage
Thioridazine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,551 documents
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Safety
Black-box Warning
Black-box warning for: Thioridazine hcl, Thioridazine hydrochloride
Adverse Events
Top Adverse Reactions
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798 adverse events reported
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