Thiopental
Pentothal (thiopental) is a small molecule pharmaceutical. Thiopental was first approved as Pentothal on 1982-01-01. It is used to treat intracranial hypertension in the USA. It is known to target voltage-gated potassium channel KCNC4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thiopental sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PENTOTHAL | Abbott Biotherapeutics | N-011679 DISCN | 1982-01-01 | 1 products |
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| intracranial hypertension | EFO_1000992 | D019586 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
58 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 2 | 2 | 4 |
| Anesthesia | D000758 | — | — | — | — | — | 2 | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | 1 | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | 1 | 1 | — | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | 1 | 1 | — | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 1 | — | 2 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 1 | 1 | 2 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | 1 | 1 | — | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | 1 | 1 | — | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Status epilepticus | D013226 | EFO_0008526 | G41 | — | — | 2 | — | 2 | 4 |
| Depression | D003863 | — | F33.9 | — | 1 | 2 | — | 1 | 3 |
| Intracranial hypertension | D019586 | EFO_1000992 | — | — | — | 1 | — | 1 | 2 |
| Hypospadias | D007021 | EFO_0004209 | Q54 | — | 1 | 1 | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | — | 1 | — | — | 1 |
| Shock | D012769 | — | R57.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esthetics | D004954 | — | — | — | 1 | — | — | — | 1 |
| Strabismus | D013285 | — | H50.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Memory disorders | D008569 | — | — | 1 | — | — | — | — | 1 |
| Amnesia | D000647 | EFO_1001454 | F44.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | — | — | 2 | 2 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | — | 1 | 1 |
| Systolic murmurs | D054160 | — | R01.1 | — | — | — | — | 1 | 1 |
| Arterial pressure | D062186 | — | — | — | — | — | — | 1 | 1 |
| Hellp syndrome | D017359 | EFO_0007297 | O14.2 | — | — | — | — | 1 | 1 |
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Thiopental |
| INN | thiopental sodium |
| Description | Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. It is the thiobarbiturate analog of pentobarbital, and an analog of thiobarbital. Sodium thiopental was a core medicine in the World Health Organization's List of Essential Medicines, but was supplanted by propofol. Despite this, thiopental is listed as an acceptable alternative to propofol, depending on local availability and cost of these agents. It was previously the first of three drugs administered during most lethal injections in the United States, but the US manufacturer Hospira stopped manufacturing the drug in 2011 and the European Union banned the export of the drug for this purpose. Although thiopental abuse carries a dependency risk, its recreational use is rare.
|
| Classification | Small molecule |
| Drug class | Barbiturate |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCC(C)C1(CC)C(=O)NC(=S)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 76-75-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL441 |
| ChEBI ID | 102166 |
| PubChem CID | 3000714 |
| DrugBank | DB00599 |
| UNII ID | 49Y44QZL70 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNC4
KCNC4
Organism
Homo sapiens
Gene name
KCNC4
Gene synonyms
C1orf30
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 4
Protein synonyms
K+ channel subunit, KSHIIIC, potassium channel, voltage gated Shaw related subfamily C, member 4, potassium voltage-gated channel, Shaw-related subfamily, member 4, Voltage-gated potassium channel subunit Kv3.4
Uniprot ID
Mouse ortholog
Kcnc4 (99738)
potassium voltage-gated channel subfamily C member 4 (Q8R1C0)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,670 adverse events reported
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