Thioguanine
Thioguanine (thioguanine) is a small molecule pharmaceutical. Thioguanine was first approved as Thioguanine on 1982-01-01. It is used to treat basophilic leukemia acute, BCR-ABL positive chronic myelogenous leukemia, eosinophilic leukemia acute, neutrophilic leukemia chronic, and psoriasis in the USA. The pharmaceutical is active against inosine-5'-monophosphate dehydrogenase 1 and inosine-5'-monophosphate dehydrogenase 2.
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Commercial
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Thioguanine
Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thioguanine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| THIOGUANINE | Waylis Therapeutics | N-012429 RX | 1982-01-01 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tabloid | New Drug Application | 2025-01-08 |
Indications
FDA
EMA
Agency Specific
FDA
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Patent Expiration
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Clinical
Clinical Trials
102 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 24 | 44 | 5 | 5 | 79 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 23 | 35 | 6 | 4 | 68 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | 18 | 29 | 5 | 3 | 56 |
| Lymphoma | D008223 | — | C85.9 | 2 | 10 | 10 | 1 | — | 20 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | 1 | — | 1 | 1 | — | 3 |
| Intestinal diseases | D007410 | HP_0002242 | K63.9 | 1 | — | — | 1 | — | 2 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | 1 | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | 10 | — | 1 | 12 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 5 | 7 | — | — | 12 |
| Myeloid leukemia | D007951 | — | C92 | — | 1 | 9 | — | 1 | 11 |
| Syndrome | D013577 | — | — | — | — | 7 | — | — | 7 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | — | 6 | — | — | 6 |
| Preleukemia | D011289 | — | — | — | — | 6 | — | — | 6 |
| Acute disease | D000208 | — | — | — | 2 | 2 | — | 1 | 5 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | 5 | — | — | 5 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | 2 | 3 | — | — | 5 |
| Philadelphia chromosome | D010677 | — | — | — | 1 | 3 | — | — | 4 |
Show 25 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | — | 1 |
| Precursor b-cell lymphoblastic leukemia-lymphoma | D015452 | — | — | — | 1 | — | — | — | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 1 | — | — | — | 1 |
| Histiocytosis | D015614 | HP_0100727 | — | — | 1 | — | — | — | 1 |
| Langerhans-cell histiocytosis | D006646 | — | C96.6 | — | 1 | — | — | — | 1 |
Show 3 more
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Chest pain | D002637 | HP_0100749 | R07.9 | — | — | — | — | 1 | 1 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | — | 1 | 1 |
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Thioguanine |
| INN | tioguanine |
| Description | Tioguanine is a 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. It has a role as an antineoplastic agent, an antimetabolite and an anticoronaviral agent. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2[nH]cnc2c(=S)[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 154-42-7 |
| RxCUI | 1546005 |
| ChEMBL ID | CHEMBL727 |
| ChEBI ID | 9555 |
| PubChem CID | 2723601 |
| DrugBank | DB00352 |
| UNII ID | WIX31ZPX66 (ChemIDplus, GSRS) |
Target
Agency Approved
IMPDH1
IMPDH1
Organism
Homo sapiens
Gene name
IMPDH1
Gene synonyms
IMPD1
NCBI Gene ID
Protein name
inosine-5'-monophosphate dehydrogenase 1
Protein synonyms
IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I
Uniprot ID
Mouse ortholog
Impdh1 (23917)
inosine-5'-monophosphate dehydrogenase 1 (P50096)
Alternate
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Variants
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Estimated US medical usage
Thioguanine
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Trends
PubMed Central
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Safety
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Adverse Events
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3,227 adverse events reported
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