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Drug ReportsThiamine
Thiamine
Berocca Pn, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Thiamine, Vitaped (thiamine) is a small molecule pharmaceutical. Thiamine was first approved as Thiamine hydrochloride on 1982-01-01. It is used to treat alcoholic neuropathy, beriberi, pellagra, thiamine deficiency, and wernicke encephalopathy in the USA. It is known to target thiamine transporter 1 and thiamine transporter 2.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
nutritional and metabolic diseasesD009750
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Thiamine (discontinued: Betalin, Thiamine)
Combinations
Infuvite (discontinued: Berocca pn, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2025-08-18
alleviaunapproved drug other2025-02-27
anubis barcelona regul oilOTC monograph final2023-09-01
bacminunapproved drug other2014-05-02
bal-care dhaunapproved drug other2012-05-01
bal-care dha essentialunapproved drug other2012-05-01
biovitaunapproved drug other2019-01-14
c-nate dhaunapproved drug other2024-01-22
centratexunapproved drug other2024-01-31
citranatal assureunapproved drug other2024-01-08
Show 73 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
alcoholic neuropathyEFO_1000803D020269G62.1
thiamine deficiency—D013832E51
wernicke encephalopathyEFO_1001241D014899E51.2
beriberiEFO_1000837D001602E51.1
pellagra—D010383—
hypercholesterolemia—D006937—
hypophosphatemiaHP_0002148D017674—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
dermatitis—D003872L30.9
Show 26 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A11: Vitamins
— A11D: Vitamin b1, plain and in combination with vitamin b6 and b12
— A11DA: Vitamin b1, plain
— A11DA01: Thiamine (vit b1)
HCPCS
Code
Description
J3411
Injection, thiamine hcl, 100 mg
Clinical
Clinical Trials
840 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnemiaD000740EFO_0004272D64.914642437
Septic shockD012772—A48.3311102729
Vitamin b 12 deficiencyD014806EFO_0000734E53.824341828
SepsisD018805EFO_0001420A41.92963825
TuberculosisD014376EFO_0000774A15-A1927121524
Hiv infectionsD015658EFO_0000764B201582823
Thiamine deficiencyD013832—E5154—5822
Vitamin d deficiencyD014808EFO_0003762E5522—31320
MalnutritionD044342EFO_0008572E40-E46—3431120
Diabetes mellitusD003920EFO_0000400E08-E1313421019
Show 117 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——5127—121
Breast neoplasmsD001943EFO_0003869C50344—616
RecurrenceD012008——662—111
Lung neoplasmsD008175—C34.90283——10
Neoplasm metastasisD009362EFO_0009708—251——8
Colorectal neoplasmsD015179——253——8
PregnancyD011247EFO_0002950Z33.12—2—48
DepressionD003863—F33.9131—48
Parkinson diseaseD010300EFO_0002508G20—12—57
AvitaminosisD001361EFO_0005878E56.9—24—37
Show 124 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———83——1121
Prostatic neoplasmsD011471—C6115——17
LymphomaD008223—C85.956———7
Multiple myelomaD009101—C90.034———6
Type 1 diabetes mellitusD003922EFO_0001359E1032——25
Pancreatic neoplasmsD010190EFO_0003860C2522———4
Hodgkin diseaseD006689—C8132———4
DeliriumD003693—R41.0—1——34
Anxiety disordersD001008EFO_0006788F41.1—1——34
Autism spectrum disorderD000067877—F84.0—2——24
Show 121 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
B-cell chronic lymphocytic leukemiaD015451—C91.12————2
Sezary syndromeD012751—C84.12————2
Mycosis fungoidesD009182—C84.02————2
T-cell lymphoma cutaneousD016410—C84.A2————2
PharmacokineticsD010599——1———12
Nutritional statusD009752——1———12
Bone fracturesD050723EFO_0003931T14.81———12
Metabolic diseasesD008659EFO_0000589E88.91———12
Heart disease risk factorsD000082742——1———12
BurnsD002056—T30.01———12
Show 43 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Iron deficienciesD000090463—E61.1————1010
Irritable bowel syndromeD043183EFO_0000555K58————44
Metabolic bone diseasesD001851——————33
ConstipationD003248—K59.0————33
FrailtyD000073496—R53.1————33
Folic acid deficiencyD005494EFO_0001070E53.8————33
Liver cirrhosisD008103EFO_0001422K74.0————33
Open-angle glaucomaD005902EFO_0004190H40.1————33
Autonomic nervous system diseasesD001342EFO_0009532G90————22
Beta-thalassemiaD017086Orphanet_848D56.1————22
Show 199 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameThiamine
INNthiamine
Description
Thiamine(1+) is a primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a primary alcohol and a vitamin B1. It is a conjugate base of a thiamine(2+).
Classification
Small molecule
Drug classVitamin
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1.[Cl-]
Identifiers
PDB—
CAS-ID59-43-8
RxCUI—
ChEMBL IDCHEMBL1588
ChEBI ID33283
PubChem CID1130
DrugBankDBSALT002650
UNII IDX66NSO3N35 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC19A2
SLC19A2
SLC19A3
SLC19A3
Organism
Homo sapiens
Gene name
SLC19A2
Gene synonyms
THT1, TRMA
NCBI Gene ID
10560
Protein name
thiamine transporter 1
Protein synonyms
high affinity thiamine transporter, reduced folate carrier protein (RFC) like, solute carrier family 19 (thiamine transporter), member 2, Solute carrier family 19 member 2, TC1, Thiamine carrier 1, thiamine-responsive megaloblastic anaemia, thTr-1
Uniprot ID
Q9UN43
Mouse ortholog
Slc19a2 (116914)
thiamine transporter 1 (Q9EQN9)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Thiamine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 65,324 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal assure, Citranatal essence, Enlyte, Healthy mamabe well rounded, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, Nestabs one, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate elite, Select ob, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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3,647 adverse events reported
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