Theophylline
Elixophyllin, Theo, Theochron, Theophylline (theophylline) is a small molecule pharmaceutical. Theophylline was first approved as Mersalyl-theophylline on 1982-01-01. It is used to treat apnea, asthma, bradycardia, bronchial spasm, and bronchitis amongst others in the USA. The pharmaceutical is active against adenosine receptor A2b and adenosine receptor A2a. In addition, it is known to target adenosine receptor A1 and adenosine receptor A3.
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Procaine merethoxylline
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Theophylline
Theophylline
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| THEOPHYLLINE 0.04% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019826 RX | 1992-08-14 | 1 products, RLD, RS |
| THEOPHYLLINE 0.08% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019826 RX | 1992-08-14 | 1 products, RLD, RS |
| THEOPHYLLINE 0.16% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019826 RX | 1992-08-14 | 1 products, RLD, RS |
| THEOPHYLLINE 0.32% AND DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019826 RX | 1992-08-14 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| senophylline | unapproved drug other | 2011-08-01 |
| theophylline in dextrose | New Drug Application | 2017-08-11 |
Indications
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ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA04: Theophylline
— R03DA54: Theophylline, combinations excl. psycholeptics
— R03DA74: Theophylline, combinations with psycholeptics
— R03DB: Xanthines and adrenergics
— R03DB04: Theophylline and adrenergics
HCPCS
Code | Description |
|---|---|
| J2810 | Injection, theophylline, per 40 mg |
Clinical
Clinical Trials
86 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 3 | 4 | 4 | 7 | 17 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 3 | 6 | 6 | 1 | 15 |
| Pseudohypoparathyroidism | D011547 | — | E20.1 | — | 4 | — | 1 | — | 5 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 1 | — | 3 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | — | — | 2 | — | 2 |
| Post-dural puncture headache | D051299 | — | — | — | — | — | 1 | 1 | 2 |
| Allergic rhinitis | D065631 | — | J30.9 | — | 1 | — | 1 | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | 1 | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | 1 | — | 1 |
| Heart block | D006327 | — | I45.89 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Altitude sickness | D000532 | EFO_1000782 | T70.29 | 2 | 1 | 1 | — | — | 3 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | 1 | 2 | 1 | — | — | 2 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | 1 | — | — | 1 |
| Disease progression | D018450 | — | — | — | — | 1 | — | — | 1 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | 1 | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 2 | — | — | — | 2 |
| Anosmia | D000086582 | — | — | — | 2 | — | — | — | 2 |
| Olfaction disorders | D000857 | HP_0000458 | R43.0 | — | 2 | — | — | — | 2 |
| Promyelocytic leukemia acute | D015473 | — | C92.4 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 1 |
| Ageusia | D000370 | EFO_1001758 | — | — | 1 | — | — | — | 1 |
| Virus diseases | D014777 | — | B34 | — | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | 1 | — | — | — | — | 1 |
| Critical illness | D016638 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Hyperuricemia | D033461 | HP_0002149 | — | 1 | — | — | — | — | 1 |
Show 1 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Headache disorders | D020773 | EFO_0009550 | G44 | — | — | — | — | 1 | 1 |
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | — | — | — | — | 1 | 1 |
| Affect | D000339 | — | — | — | — | — | — | 1 | 1 |
| Skin care | D017592 | — | — | — | — | — | — | 1 | 1 |
| Syncope | D013575 | HP_0012668 | G90.01 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Theophylline |
| INN | — |
| Description | Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, an anti-asthmatic drug, an anti-inflammatory agent, an immunomodulator, an adenosine receptor antagonist, a drug metabolite, a fungal metabolite and a human blood serum metabolite. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2[nH]cnc2n(C)c1=O |
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Theophylline
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Hydroxyzine
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Ephedrine
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Theophylline
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Guaifenesin
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Theophylline
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4,492 adverse events reported
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