Thalomid, Thalidomide bms (previously thalidomide celgene)(thalidomide)
Thalomid (thalidomide) is a small molecule pharmaceutical. Thalidomide was first approved as Thalomid on 1998-07-16. It is used to treat aphthous stomatitis, behcet syndrome, crohn disease, discoid lupus erythematosus, and erythema multiforme amongst others in the USA. It has been approved in Europe to treat multiple myeloma. It is known to target protein cereblon.
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Commercial
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Thalomid (generic drugs available since 2023-04-27)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Thalidomide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| THALOMID | Bristol Myers Squibb | N-020785 RX | 1998-07-16 | 4 products, RLD |
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Clinical
Clinical Trials
516 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 25 | 77 | 55 | 4 | 10 | 154 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 14 | 2 | 1 | 2 | 21 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 7 | 2 | 1 | — | 10 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | 1 | 4 | 1 | — | 6 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | — | 5 | — | 1 | — | 6 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | 1 | 1 | 1 | 1 | 1 | 5 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | 2 | — | 1 | — | 3 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | — | 1 | — | 1 | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | — | — | 1 | 1 | 2 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 1 | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 8 | 12 | 3 | — | — | 21 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 13 | 4 | — | 1 | 19 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 13 | 6 | — | 1 | 16 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 11 | 1 | — | — | 12 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 9 | 5 | — | 1 | 11 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 2 | 3 | — | 3 | 8 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 5 | 2 | — | — | 7 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | 4 | 1 | — | — | 5 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | 3 | 2 | — | — | 5 |
| Colorectal neoplasms | D015179 | — | — | — | 3 | 1 | — | — | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 8 | — | — | 2 | 11 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 10 | — | — | 1 | 11 |
| Melanoma | D008545 | — | — | 3 | 9 | — | — | — | 11 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 6 | — | — | 3 | 11 |
| Central nervous system neoplasms | D016543 | — | — | 1 | 9 | — | — | — | 10 |
| Lymphoma | D008223 | — | C85.9 | 2 | 7 | — | — | — | 9 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 7 | — | — | 1 | 8 |
| Sarcoma | D012509 | — | — | — | 6 | — | — | — | 6 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 4 | — | — | — | 5 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 3 | — | — | 1 | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Liposarcoma | D008080 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary sarcoidosis | D017565 | DOID_13406 | D86.0 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Retinoblastoma | D012175 | — | — | 1 | — | — | — | — | 1 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 1 | — | — | — | — | 1 |
| Rhabdomyosarcoma | D012208 | — | — | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors | D018242 | — | — | 1 | — | — | — | — | 1 |
| Wilms tumor | D009396 | EFO_0000212 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | — | — | — | 1 | 1 |
| Bone marrow transplantation | D016026 | — | — | — | — | — | — | 1 | 1 |
| Adrenoleukodystrophy | D000326 | Orphanet_43 | E71.52 | — | — | — | — | 1 | 1 |
| Cutaneous lupus erythematosus | D008178 | EFO_0003834 | L93.1 | — | — | — | — | 1 | 1 |
| Mothers | D009035 | — | — | — | — | — | — | 1 | 1 |
| Leukapheresis | D007937 | — | — | — | — | — | — | 1 | 1 |
| Survivorship | D000073859 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Thalidomide |
| INN | thalidomide |
| Description | 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione is a dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group. It is a member of piperidones and a member of phthalimides. |
| Classification | Small molecule |
| Drug class | thalidomide derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1 |
Identifiers
| PDB | — |
| CAS-ID | 1012310-87-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL468 |
| ChEBI ID | 74947 |
| PubChem CID | 5426 |
| DrugBank | DB01041 |
| UNII ID | 4Z8R6ORS6L (ChemIDplus, GSRS) |
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Thalomid – Celgene
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Safety
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32,879 adverse events reported
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