Tezosentan
Veletri (tezosentan) is a small molecule pharmaceutical. Tezosentan was first approved as Veletri on 2008-06-27.
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Brand Name | Status | Last Update |
|---|---|---|
| veletri | New Drug Application | 2022-11-28 |
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Clinical
Clinical Trials
113 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | — | 2 | 1 | — | — | 2 |
| Renal insufficiency | D051437 | — | N19 | — | 2 | 1 | — | — | 2 |
| Nephrosclerosis | D009400 | EFO_1000041 | I12 | — | 2 | 1 | — | — | 2 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tezosentan |
| INN | tezosentan |
| Description | Tezosentan is a non-selective ETA and ETB receptor antagonist. It acts as a vasodilator and was designed by Actelion as a therapy for patients with acute heart failure. However, studies showed that tezosentan did not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.
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| Classification | Small molecule |
| Drug class | endothelin receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nnn[nH]3)c2)nc1OCCO |
Identifiers
| PDB | — |
| CAS-ID | 180384-57-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL61780 |
| ChEBI ID | — |
| PubChem CID | 151174 |
| DrugBank | — |
| UNII ID | 64J9J55263 (ChemIDplus, GSRS) |
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Safety
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8,534 adverse events reported
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