Tezosentan
Tezosentan is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| veletri | New Drug Application | 2022-11-28 |
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Clinical Trials
103 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 12 | 11 | 16 | 17 | 58 |
| Pulmonary arterial hypertension | D000081029 | — | — | 2 | 10 | 9 | 12 | 13 | 46 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | 1 | 9 | 9 | 8 | 8 | 35 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | 6 | 7 | 8 | 11 | 33 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 3 | 1 | 1 | 5 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | 2 | 1 | 1 | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 2 | 2 | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 2 | 1 | 1 | — | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | 1 | 1 | 3 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | 2 | — | 2 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | 3 | 4 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 1 | 3 | — | — | 4 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | 3 | — | — | 4 |
| Respiratory tract diseases | D012140 | — | — | — | — | 3 | — | — | 3 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | 3 | — | — | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 2 | 1 | — | — | 2 |
| Nephrosclerosis | D009400 | EFO_1000041 | I12 | — | 2 | 1 | — | — | 2 |
| Liver transplantation | D016031 | EFO_0010682 | — | — | 1 | 1 | — | — | 1 |
| Septic shock | D012772 | — | A48.3 | — | 1 | 1 | — | — | 1 |
| Shock | D012769 | — | R57.1 | — | 1 | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | — | T14.8 | 2 | 2 | — | — | — | 3 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | 2 | 3 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | 2 | — | — | — | 2 |
| Reperfusion injury | D015427 | — | — | 1 | 2 | — | — | — | 2 |
| Covid-19 | D000086382 | — | — | — | 2 | — | — | — | 2 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 2 | — | — | — | 2 |
| Schistosomiasis | D012552 | EFO_1001475 | B65 | — | 1 | — | — | — | 1 |
| Delayed graft function | D051799 | — | — | 1 | 1 | — | — | — | 1 |
| Persistent fetal circulation syndrome | D010547 | EFO_1001103 | P29.3 | — | 1 | — | — | — | 1 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34.0 | — | 1 | — | — | — | 1 |
Show 12 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Headache | D006261 | HP_0002315 | R51 | 1 | — | — | — | 1 | 2 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | — | — | — | — | 1 |
| Brain injuries | D001930 | — | S06.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | — | — | — | 3 | 3 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | — | — | 2 | 2 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | — | 2 | 2 |
| Syndrome | D013577 | — | — | — | — | — | — | 2 | 2 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| Eisenmenger complex | D004541 | — | I27.83 | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | HP_0000855 | — | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Essential hypertension | D000075222 | — | I10 | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tezosentan |
| INN | tezosentan |
| Description | Tezosentan is a non-selective ETA and ETB receptor antagonist. It acts as a vasodilator and was designed by Actelion as a therapy for patients with acute heart failure. However, studies showed that tezosentan did not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.
|
| Classification | Small molecule |
| Drug class | endothelin receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nnn[nH]3)c2)nc1OCCO |
Identifiers
| PDB | — |
| CAS-ID | 180384-57-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL61780 |
| ChEBI ID | — |
| PubChem CID | 151174 |
| DrugBank | — |
| UNII ID | 64J9J55263 (ChemIDplus, GSRS) |
Target
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Trends
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Additional graphs summarizing 349 documents
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Safety
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Adverse Events
Top Adverse Reactions
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8,419 adverse events reported
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