Tetracycline
Achromycin, Bismuth / Metronidazole / Tetracycline, Pylera, Sumycin, Tetracycline, Tetracyn, Tetrex (tetracycline) is a small molecule pharmaceutical. Tetracycline was first approved as Achromycin on 1982-01-01. It is used to treat acne vulgaris, bacterial eye infections, bacterial infections, bartonella infections, and borrelia infections amongst others in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Achromycin, Sumycin, Tetracycline (discontinued: Achromycin, Actisite, Bristacycline, Cyclopar, Panmycin, Retet, Robitet, Sumycin, Tetracycline, Tetracyn, Tetramed, Tetrex, Topicycline)
CombinationsBismuth subcitrate potassium, metronidazole tetracycline, Bismuth subsalicylate, metronidazole tetracycline (discontinued: Achromycin, Helidac, Tetracyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrocortisone
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Tetracycline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ACHROMYCIN | Lederle Laboratories | N-050272 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Procaine hydrochloride
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Tetracycline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ACHROMYCIN | Lederle Laboratories | N-050276 DISCN | 1982-01-01 | 2 products |
Hide discontinued
Tetracycline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ACHROMYCIN V | Avet Pharmaceuticals | N-050278 RX | 1982-01-01 | 2 products, RLD |
Show 6 discontinued
Bismuth subsalicylate
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Metronidazole
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Tetracycline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HELIDAC | Casper Pharma | N-050719 DISCN | 1996-08-15 | 1 products, RLD |
Hide discontinued
Tetracycline phosphate complex
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TETREX | Bristol Myers Squibb | N-050212 DISCN | 1982-01-01 | 2 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acnecycline | OTC monograph final | 2011-02-15 |
| anistem | C200263 | 2023-12-01 |
| apt t3x tetracycline hydrochloride first aid antibiotic | C200263 | 2023-12-01 |
| bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride | ANDA | 2023-03-06 |
| bismuth subcitrate potassium, metronidazole, and tetracycline hydrochloride | New Drug Application | 2024-07-25 |
| bismuth subcitrate potassium, metronidazole, tetracycline hydrochloride | ANDA | 2024-10-22 |
| bismuth subsalicylate/metronidazole/tetracycline hydrochloride | ANDA | 2019-11-24 |
| bwell first aid antibiotic | C200263 | 2023-11-30 |
| dermacline | OTC monograph final | 2016-11-08 |
| diabecline | OTC monograph final | 2013-07-12 |
Show 19 more
Indications
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EMA
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Agency Specific
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB13: Tetracycline
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BD: Combinations for eradication of helicobacter pylori
— A02BD02: Lansoprazole, tetracycline and metronidazole
— A02BD08: Bismuth subcitrate, tetracycline and metronidazole
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AA: Tetracycline and derivatives, topical antibiotics
— D06AA04: Tetracycline
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01A: Tetracycline antibiotics
— J01AA: Tetracyclines
— J01AA07: Tetracycline
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA08: Tetracycline and oleandomycin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA09: Tetracycline
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA08: Tetracycline
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA02: Tetracycline
Clinical
Clinical Trials
216 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | 5 | 50 | 33 | 89 |
| Helicobacter infections | D016481 | EFO_1000961 | — | 2 | 1 | 3 | 25 | 15 | 45 |
| Communicable diseases | D003141 | — | — | 1 | — | 1 | 14 | 11 | 27 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | 1 | — | 1 | 8 | 4 | 14 |
| Disease susceptibility | D004198 | — | — | — | — | — | 9 | 1 | 10 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | 2 | 3 | 1 | 7 |
| Bacterial infections | D001424 | — | A49 | 3 | — | — | 1 | 2 | 6 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 1 | 1 | — | 1 | 1 | 4 |
| Trachoma | D014141 | — | A71 | — | — | 1 | 2 | — | 3 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | 1 | — | 2 | — | 3 |
Show 33 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 1 | 1 | — | 1 | 4 |
| Candidiasis | D002177 | — | B37 | — | — | 2 | — | — | 2 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | — | — | 2 | — | — | 2 |
| Vaginal diseases | D014623 | — | — | — | — | 2 | — | — | 2 |
| Burns | D002056 | — | T30.0 | — | 2 | 2 | — | — | 2 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | 1 | 2 | 1 | — | — | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | 1 | — | — | 2 |
| Bone diseases | D001847 | — | M89.9 | — | 1 | 1 | — | 1 | 2 |
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | — | — | 1 | — | — | 1 |
| Eye burns | D005126 | EFO_1001788 | — | — | 1 | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Exanthema | D005076 | HP_0000988 | — | — | 2 | — | — | 1 | 3 |
| Lymphoma | D008223 | — | C85.9 | — | 3 | — | — | — | 3 |
| Dental pulp necrosis | D003790 | — | K04.1 | 1 | 2 | — | — | 1 | 3 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | 1 | 2 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | 1 | — | — | 1 | 2 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 2 | — | — | — | 2 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | 2 | — | — | — | 2 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 1 | — | — | 1 | 2 |
Show 38 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | — | 1 | — | — | — | 2 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | 1 | 3 |
| Recurrence | D012008 | — | — | 1 | — | — | — | 1 | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | — | — | — | — | 1 |
| Hemangioma | D006391 | — | D18.0 | 1 | — | — | — | — | 1 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | 1 | — | — | — | — | 1 |
| Intracranial arteriovenous malformations | D002538 | EFO_0003916 | Q28.2 | 1 | — | — | — | — | 1 |
| Arteriovenous malformations | D001165 | — | — | 1 | — | — | — | — | 1 |
| Aphthous stomatitis | D013281 | HP_0011107 | K12.0 | 1 | — | — | — | — | 1 |
Show 13 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Seroma | D049291 | — | — | — | — | — | — | 2 | 2 |
| Patient compliance | D010349 | — | — | — | — | — | — | 2 | 2 |
| Surgical wound infection | D013530 | — | — | — | — | — | — | 2 | 2 |
| Gingival recession | D005889 | — | K06.0 | — | — | — | — | 2 | 2 |
| Child mortality | D046688 | — | — | — | — | — | — | 1 | 1 |
| Pneumococcal pneumonia | D011018 | EFO_1001474 | J13 | — | — | — | — | 1 | 1 |
| Pneumococcal infections | D011008 | EFO_0000772 | J13 | — | — | — | — | 1 | 1 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
Show 43 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tetracycline |
| INN | tetracycline |
| Description | Tetracycline is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. It has a role as an antimicrobial agent, an antibacterial drug, an antiprotozoal drug, a protein synthesis inhibitor and an Escherichia coli metabolite. It is a tertiary alpha-hydroxy ketone and a member of tetracyclines. It is a conjugate acid of a tetracycline(1-) and a tetracycline zwitterion. |
| Classification | Small molecule |
| Drug class | antibiotics (tetracycline derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 60-54-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1440 |
| ChEBI ID | 27902 |
| PubChem CID | 54675776 |
| DrugBank | DB00759 |
| UNII ID | F8VB5M810T (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Tetracycline
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 44,400 documents
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Safety
Black-box Warning
Black-box warning for: Bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride, Bismuth subcitrate potassium, metronidazole, and tetracycline hydrochloride, Bismuth subcitrate potassium, metronidazole, tetracycline hydrochloride, Bismuth subsalicylate/metronidazole/tetracycline hydrochloride, Helidac therapy, Pylera
Adverse Events
Top Adverse Reactions
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4,254 adverse events reported
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