Tetrabenazine
Tetrabenazine, Xenazine (tetrabenazine) is a small molecule pharmaceutical. Tetrabenazine was first approved as Xenazine on 2008-08-15. It is used to treat huntington disease and hyperkinesis in the USA. The pharmaceutical is active against synaptic vesicular amine transporter. In addition, it is known to target chromaffin granule amine transporter.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Tetrabenazine, Xenazine (discontinued: Tetrabenazine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tetrabenazine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XENAZINE | Bausch Health Companies | N-021894 RX | 2008-08-15 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tetrabenazine | ANDA | 2024-10-01 |
| xenazine | New Drug Application | 2022-06-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| huntington disease | Orphanet_399 | D006816 | G10 |
| hyperkinesis | HP_0000752 | D006948 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Huntington disease | D006816 | Orphanet_399 | G10 | 2 | — | 5 | 2 | 1 | 10 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | — | 1 |
| Cerebral palsy | D002547 | — | G80 | — | — | — | 1 | — | 1 |
| Impulsive behavior | D007175 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tardive dyskinesia | D000071057 | — | G24.01 | — | 3 | 1 | — | — | 4 |
| Dyskinesias | D020820 | HP_0002310 | G24 | — | 3 | 1 | — | — | 4 |
| Chorea | D002819 | EFO_0004152 | G25.5 | — | — | 3 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | — | — | 2 | 4 |
| Psychotic disorders | D011618 | — | F20.81 | — | 2 | — | — | 2 | 4 |
| Tourette syndrome | D005879 | EFO_0004895 | F95.2 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Emergencies | D004630 | — | — | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Movement disorders | D009069 | HP_0100022 | — | — | — | — | — | 1 | 1 |
| Hyperkinesis | D006948 | HP_0000752 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Tetrabenazine |
| INN | tetrabenazine |
| Description | 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one is a benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7. It is a benzoquinolizine, a cyclic ketone and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2 |
Identifiers
| PDB | — |
| CAS-ID | 58-46-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL117785 |
| ChEBI ID | 64028 |
| PubChem CID | 6018 |
| DrugBank | DB04844 |
| UNII ID | Z9O08YRN8O (ChemIDplus, GSRS) |
Target
Agency Approved
SLC18A2
SLC18A2
Organism
Homo sapiens
Gene name
SLC18A2
Gene synonyms
SVMT, VMAT2
NCBI Gene ID
Protein name
synaptic vesicular amine transporter
Protein synonyms
monoamine neurotransmitter transporter, Monoamine transporter, solute carrier family 18 (vesicular monoamine transporter), member 2, Solute carrier family 18 member 2, synaptic vesicle amine transporter, brain, synaptic vesicle monoamine transporter, brain, VAT2, vesicle monoamine transporter type 2, vesicle monoamine/H+ antiporter, Vesicular amine transporter 2
Uniprot ID
Mouse ortholog
Slc18a2 (214084)
synaptic vesicular amine transporter (Q8CC55)
Alternate
SLC18A1
SLC18A1
Organism
Homo sapiens
Gene name
SLC18A1
Gene synonyms
VAT1, VMAT1
NCBI Gene ID
Protein name
chromaffin granule amine transporter
Protein synonyms
solute carrier family 18 (vesicular monoamine transporter), member 1, solute carrier family 18 (vesicular monoamine), member 1, Solute carrier family 18 member 1, VAT1, Vesicular amine transporter 1
Uniprot ID
Mouse ortholog
Slc18a1 (110877)
chromaffin granule amine transporter (Q8R090)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 2,533 documents
View more details
Safety
Black-box Warning
Black-box warning for: Tetrabenazine, Xenazine
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
11,596 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use