Terfenadine
Terfenadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target potassium voltage-gated channel subfamily H member 2, potassium voltage-gated channel subfamily H member 1, and cytochrome P450 2J2.
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Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 24/7 life allergy relief | OTC monograph final | 2023-07-19 |
| all day allergy | ANDA | 2017-12-08 |
| allergy antihistamine | C200263 | 2024-01-10 |
| allergy relief antihistamine | OTC monograph final | 2023-07-25 |
| allergy relief diphenhydramine hci 25 mg antihistamine | OTC monograph final | 2022-06-22 |
| allergy relief diphenhydramine hci, 25 mg antihistamine | OTC monograph final | 2021-12-06 |
| allergy relief diphenhydramine hcl 25 mg antihistamine | OTC monograph final | 2023-04-27 |
| allergy relief diphenhydramine hcl, 25 mg antihistamine | C200263 | 2023-12-16 |
| circle k allergy | C200263 | 2023-12-14 |
| coricidin hbp cough and cold | C200263 | 2023-11-30 |
Show 10 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic rhinitis | — | D065631 | J30.9 |
| allergic rhinitis seasonal | EFO_0003956 | D006255 | J30 |
| skin diseases | — | D012871 | L00-L99 |
Agency Specific
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Clinical
Clinical Trials
1410 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 94 | 1 | 2 | 4 | 12 | 112 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | 2 | 16 | 38 | 28 | 8 | 91 |
| Allergic rhinitis | D065631 | — | J30.9 | 6 | 15 | 20 | 35 | 9 | 84 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | 1 | 7 | 30 | 26 | 6 | 69 |
| Chronic urticaria | D000080223 | — | L50.8 | 1 | 15 | 22 | 8 | 4 | 49 |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | — | 1 | 22 | 14 | 3 | 40 |
| Rhinitis | D012220 | EFO_0008521 | J31 | 3 | 5 | 10 | 5 | 8 | 30 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 11 | 7 | 3 | 9 | 27 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 11 | 1 | 4 | 8 | 2 | 25 |
| Neoplasms | D009369 | — | C80 | 8 | 15 | 3 | 1 | — | 24 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 7 | 3 | — | 2 | 12 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 4 | 2 | — | 1 | 11 |
| Lymphoma | D008223 | — | C85.9 | 1 | 5 | 1 | — | 1 | 8 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | 1 | 1 | 5 | — | — | 7 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 4 | 1 | — | 1 | 7 |
| Sleep wake disorders | D012893 | — | G47 | — | — | 5 | — | 2 | 7 |
| Respiratory tract infections | D012141 | — | J06.9 | 1 | — | 4 | — | 1 | 6 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 3 | — | 2 | 5 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | 2 | 3 | — | — | 5 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 2 | 4 | — | — | 5 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 5 | — | — | 1 | 8 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 7 | — | — | 1 | 8 |
| Colorectal neoplasms | D015179 | — | — | 3 | 4 | — | — | — | 6 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 4 | 2 | — | — | — | 5 |
| Hepatitis b | D006509 | — | — | 1 | 4 | — | — | — | 5 |
| Anorexia | D000855 | HP_0002039 | R63.0 | — | 4 | — | — | 1 | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | — | — | 2 | 4 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 2 | 2 | — | — | — | 4 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 2 | — | — | 2 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | 4 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 4 | — | — | — | 2 | 6 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | — | — | — | 2 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | — | 1 | 3 |
| Biological availability | D001682 | — | — | 3 | — | — | — | — | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 2 | — | — | — | — | 2 |
| Hairy cell leukemia | D007943 | — | C91.4 | 2 | — | — | — | — | 2 |
| Fasting | D005215 | EFO_0002756 | — | 2 | — | — | — | — | 2 |
| Papillary thyroid cancer | D000077273 | — | — | 2 | — | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | — | 1 | 2 |
Show 38 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 5 | 5 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | — | 4 | 4 |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | — | — | 3 | 3 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 2 | 2 |
| Endoscopy | D004724 | — | — | — | — | — | — | 2 | 2 |
| Benign paroxysmal positional vertigo | D065635 | — | — | — | — | — | — | 2 | 2 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 2 | 2 |
| Long-term memory | D057567 | — | — | — | — | — | — | 1 | 1 |
| Short-term memory | D008570 | EFO_0004335 | — | — | — | — | — | 1 | 1 |
| Papillomaviridae | D027383 | — | — | — | — | — | — | 1 | 1 |
Show 64 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Terfenadine |
| INN | terfenadine |
| Description | Terfenadine is a diarylmethane. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 50679-08-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17157 |
| ChEBI ID | 9453 |
| PubChem CID | 5405 |
| DrugBank | DB00342 |
| UNII ID | 7BA5G9Y06Q (ChemIDplus, GSRS) |
Target
Alternate
KCNH2
KCNH2
KCNH1
KCNH1
CYP2J2
CYP2J2
Organism
Homo sapiens
Gene name
KCNH2
Gene synonyms
ERG, ERG1, HERG
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily H member 2
Protein synonyms
Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, human ether-a-go-go-related, long QT syndrome type 2, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, Voltage-gated potassium channel subunit Kv11.1
Uniprot ID
Mouse ortholog
Kcnh2 (16511)
potassium voltage-gated channel subfamily H member 2 (O35989)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Terfenadine
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Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Terfenadine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Additional graphs summarizing 19,251 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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445 adverse events reported
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