Terfenadine
Terfenadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target voltage-gated inwardly rectifying potassium channel KCNH2; potassium voltage-gated channel subfamily H member 2, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, and cytochrome P450 2J2.
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Commercial
Therapeutic Areas
Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 24/7 life allergy relief | C200263 | 2024-12-30 |
| all day allergy | ANDA | 2012-12-20 |
| allergy antihistamine | C200263 | 2024-01-10 |
| allergy relief antihistamine | C200263 | 2024-12-16 |
| allergy relief diphenhydramine hci 25 mg antihistamine | C200263 | 2024-11-20 |
| allergy relief diphenhydramine hci, 25 mg antihistamine | C200263 | 2024-11-20 |
| allergy relief diphenhydramine hcl 25 mg antihistamine | C200263 | 2024-11-20 |
| allergy relief diphenhydramine hcl, 25 mg antihistamine | C200263 | 2023-12-16 |
| allexpert 24hr antihistamine cetirizine hydrochloride oral solution | unapproved drug other | 2024-04-17 |
| childrens allergy relief | OTC monograph final | 2014-10-27 |
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Indications
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Clinical
Clinical Trials
1525 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Allergic rhinitis | D065631 | — | J30.9 | — | 2 | 4 | 2 | 1 | 9 |
| Rhinitis | D012220 | EFO_0008521 | J31 | — | 2 | 4 | 2 | 1 | 9 |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | — | — | 1 | 2 | 1 | 4 |
| Conjunctivitis | D003231 | — | H10 | — | — | — | 2 | — | 2 |
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | — | — | 2 | — | 2 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | 1 | — | 7 | — | — | 8 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | — | 1 | 3 | — | 1 | 5 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | 1 | — | 4 | — | — | 5 |
| Sleep wake disorders | D012893 | — | G47 | — | — | 4 | — | — | 4 |
| Dyssomnias | D020920 | — | — | — | — | 4 | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | 2 | — | — | 3 |
| Parasomnias | D020447 | — | G47.5 | — | — | 3 | — | — | 3 |
| Intrinsic sleep disorders | D020919 | — | F51.03 | — | — | 3 | — | — | 3 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | 2 | — | — | 3 |
| Hot flashes | D019584 | — | — | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 2 | 1 | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | 2 | — | — | — | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | — | — | — | 1 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | 1 | — | — | — | 1 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 1 | 1 | — | — | — | 1 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 1 | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | 1 | — | — | — | 1 |
| Non-muscle invasive bladder neoplasms | D000093284 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | 1 | — | — | — | — | 1 |
| Heartburn | D006356 | — | R12 | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Terfenadine |
| INN | terfenadine |
| Description | Terfenadine is a diarylmethane. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 50679-08-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL17157 |
| ChEBI ID | 9453 |
| PubChem CID | 5405 |
| DrugBank | DB00342 |
| UNII ID | 7BA5G9Y06Q (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
KCNH2
KCNH2
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH2
Gene synonyms
ERG, ERG1, HERG
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily H member 2
Protein synonyms
Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, human ether-a-go-go-related, long QT syndrome type 2, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, Voltage-gated potassium channel subunit Kv11.1
Uniprot ID
Mouse ortholog
Kcnh2 (16511)
potassium voltage-gated channel subfamily H member 2 (O35989)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Terfenadine
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Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Terfenadine
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Trends
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Safety
Black-box Warning
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Adverse Events
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506 adverse events reported
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