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AboutPricing
Drug ReportsTerfenadine
Terfenadine
Terfenadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target voltage-gated inwardly rectifying potassium channel KCNH2; potassium voltage-gated channel subfamily H member 2, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, and cytochrome P450 2J2.
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1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
allergy antihistamineC2002632024-01-10
allergy relief antihistamineC2002632024-12-16
allexpert 24hr antihistamine cetirizine hydrochloride oral solutionunapproved drug other2024-04-17
childrens allergy reliefOTC monograph final2014-10-27
circle k allergyC2002632023-12-14
coricidin hbp cough and coldC2002632025-12-05
deltuss dmx cough suppressant nasal decongestant antihistamine grape flavorOTC monograph final2021-11-02
deltuss dp nasal decongestant antihistamine cherry flavorOTC monograph final2021-11-02
loratadineANDA2026-02-26
loratadineantihistamineANDA2013-05-20
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AX: Other antihistamines for systemic use in atc
— R06AX12: Terfenadine
HCPCS
No data
Clinical
Clinical Trials
385 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9——11—2
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35——3——3
Chronic progressive multiple sclerosisD020528EFO_0003840———2——2
Relapsing-remitting multiple sclerosisD020529EFO_0003929———2——2
SclerosisD012598————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228—C85.9—1———1
LymphomaD008223—C85.9—1———1
Large b-cell lymphoma diffuseD016403—C83.3—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C951————1
B-cell chronic lymphocytic leukemiaD015451—C91.11————1
Lymphoid leukemiaD007945—C911————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTerfenadine
INNterfenadine
Description
Terfenadine is a diarylmethane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Identifiers
PDB—
CAS-ID50679-08-8
RxCUI—
ChEMBL IDCHEMBL17157
ChEBI ID9453
PubChem CID5405
DrugBankDB00342
UNII ID7BA5G9Y06Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNH2
KCNH2
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH2
Gene synonyms
ERG, ERG1, HERG
NCBI Gene ID
3757
Protein name
potassium voltage-gated channel subfamily H member 2
Protein synonyms
Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, human ether-a-go-go-related, long QT syndrome type 2, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, Voltage-gated potassium channel subunit Kv11.1
Uniprot ID
Q9H3P0
Mouse ortholog
Kcnh2 (16511)
potassium voltage-gated channel subfamily H member 2 (O35989)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Terfenadine
+
Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Terfenadine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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507 adverse events reported
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