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AboutPricing
Drug ReportsTerfenadine
Terfenadine
Terfenadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target voltage-gated inwardly rectifying potassium channel KCNH2; potassium voltage-gated channel subfamily H member 2, voltage-gated delayed rectifier potassium channel KCNH1; potassium voltage-gated channel subfamily H member 1, and cytochrome P450 2J2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
24/7 life allergy reliefC2002632024-12-30
all day allergyANDA2012-12-20
allergy antihistamineC2002632024-01-10
allergy relief antihistamineC2002632024-12-16
allergy relief diphenhydramine hci 25 mg antihistamineC2002632024-11-20
allergy relief diphenhydramine hci, 25 mg antihistamineC2002632024-11-20
allergy relief diphenhydramine hcl 25 mg antihistamineC2002632024-11-20
allergy relief diphenhydramine hcl, 25 mg antihistamineC2002632023-12-16
allexpert 24hr antihistamine cetirizine hydrochloride oral solutionunapproved drug other2024-04-17
childrens allergy reliefOTC monograph final2014-10-27
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AX: Other antihistamines for systemic use in atc
— R06AX12: Terfenadine
HCPCS
No data
Clinical
Clinical Trials
1514 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Biological availabilityD001682——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTerfenadine
INNterfenadine
Description
Terfenadine is a diarylmethane.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1
Identifiers
PDB—
CAS-ID50679-08-8
RxCUI—
ChEMBL IDCHEMBL17157
ChEBI ID9453
PubChem CID5405
DrugBankDB00342
UNII ID7BA5G9Y06Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNH2
KCNH2
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNH2
Gene synonyms
ERG, ERG1, HERG
NCBI Gene ID
3757
Protein name
potassium voltage-gated channel subfamily H member 2
Protein synonyms
Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, ether-a-go-go-related potassium channel protein, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, human ether-a-go-go-related, long QT syndrome type 2, potassium channel, voltage gated eag related subfamily H, member 2, potassium voltage-gated channel, subfamily H (eag-related), member 2, Voltage-gated potassium channel subunit Kv11.1
Uniprot ID
Q9H3P0
Mouse ortholog
Kcnh2 (16511)
potassium voltage-gated channel subfamily H member 2 (O35989)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Terfenadine
+
Pseudoephedrine
Total medical expenditures per year (USD, in millions)
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Terfenadine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21,139 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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499 adverse events reported
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