Teplizumab
Tzield (teplizumab) is an antibody pharmaceutical. Teplizumab was first approved as Tzield on 2022-11-17. It is used to treat type 1 diabetes mellitus in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Tzield
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Teplizumab
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Tzield | teplizumab-mzwv | Provention Bio | N-761183 RX | 2022-11-17 | 1 products |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tzield | Biologic Licensing Application | 2025-05-06 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 1 diabetes mellitus | EFO_0001359 | D003922 | E10 |
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
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Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 6 | 11 | 4 | 1 | 5 | 23 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 3 | 7 | 3 | 1 | 4 | 16 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 4 | — | — | — | 5 |
| Precursor b-cell lymphoblastic leukemia-lymphoma | D015452 | — | — | 1 | 2 | — | — | — | 3 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 2 | — | — | — | 2 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | 1 | — | — | — | 1 |
| Philadelphia chromosome | D010677 | — | — | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | — | — | — | 1 |
Show 18 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Intestinal neoplasms | D007414 | — | C26.0 | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Teplizumab |
| INN | teplizumab |
| Description | Teplizumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743078 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06606 |
| UNII ID | S4M959U2IJ (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Tzield – Sanofi
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 1,436 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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348 adverse events reported
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