Tnkase, Metalyse(tenecteplase)
Metalyse, TNKase (tenecteplase) is an enzyme pharmaceutical. Tenecteplase was first approved as Tnkase on 2000-06-02. It is used to treat coronary thrombosis and myocardial infarction in the USA. It has been approved in Europe to treat myocardial infarction.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Tnkase
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tnkase | Biologic Licensing Application | 2025-04-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myocardial infarction | EFO_0000612 | D009203 | I21 |
| coronary thrombosis | EFO_1000883 | D003328 | I21 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3101 | ["Injection, tenecteplase, 1 mg"] |
Clinical
Clinical Trials
127 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 5 | 2 | 3 | 10 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 5 | 2 | 3 | 10 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 3 | — | — | 3 |
| Ischemic stroke | D000083242 | — | — | — | — | 2 | — | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | 2 | — | — | 2 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | 1 | — | — | 1 |
| Embolism | D004617 | — | — | — | — | 1 | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tenecteplase |
| INN | tenecteplase |
| Description | Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug.
|
| Classification | Enzyme |
| Drug class | enzymes: tissue-type plasminogen activators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108791 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00031 |
| UNII ID | WGD229O42W (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,713 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,806 adverse events reported
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