Tnkase, Metalyse(tenecteplase)
Metalyse, TNKase (tenecteplase) is an enzyme pharmaceutical. Tenecteplase was first approved as Tnkase on 2000-06-02. It is used to treat coronary thrombosis and myocardial infarction in the USA. It has been approved in Europe to treat myocardial infarction.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Tnkase
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tnkase | Biologic Licensing Application | 2025-04-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myocardial infarction | EFO_0000612 | D009203 | I21 |
| coronary thrombosis | EFO_1000883 | D003328 | I21 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J3101 | ["Injection, tenecteplase, 1 mg"] |
Clinical
Clinical Trials
140 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 1 | 22 | 40 | 7 | 12 | 75 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 17 | 29 | 5 | 12 | 61 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 2 | 8 | 5 | 7 | 21 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | 6 | 6 | 3 | 5 | 21 |
| Infarction | D007238 | EFO_0009463 | — | — | 3 | 4 | 5 | 7 | 18 |
| Cerebral infarction | D002544 | — | I63 | 1 | 5 | 3 | 1 | 3 | 12 |
| St elevation myocardial infarction | D000072657 | — | — | — | 2 | 3 | 3 | 2 | 9 |
| Thrombosis | D013927 | — | — | — | 2 | 5 | 2 | — | 9 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | 1 | 2 | 1 | 1 | 5 |
| Embolism | D004617 | — | — | — | 1 | 1 | 1 | 1 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 3 | — | 3 | — | 1 | 7 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | 1 | 3 | 3 | — | 1 | 6 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 4 | 2 | — | 1 | 5 |
| Cerebral hemorrhage | D002543 | — | — | 3 | — | 1 | — | 1 | 5 |
| Brain diseases | D001927 | — | G93.40 | — | 3 | 2 | — | 1 | 4 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | 2 | 1 | 1 | — | — | 4 |
| Intracranial thrombosis | D020767 | — | — | — | 1 | 3 | — | — | 3 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 2 | 1 | — | 1 | 3 |
| Central nervous system diseases | D002493 | — | G96.9 | — | 3 | 2 | — | — | 3 |
| Retinal artery occlusion | D015356 | EFO_1001154 | H34.1 | — | — | 2 | — | — | 2 |
Show 14 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | — | 2 | — | — | — | 2 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | 1 | — | — | — | 1 |
| Ventricular dysfunction | D018754 | — | — | — | 1 | — | — | — | 1 |
| Brain infarction | D020520 | EFO_0004277 | I63 | — | 1 | — | — | — | 1 |
| Pathologic processes | D010335 | — | — | — | 1 | — | — | — | 1 |
| Cerebral arterial diseases | D002539 | EFO_1000859 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | — | — | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | — | — | — | — | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
| Cerebral intraventricular hemorrhage | D000074042 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Necrosis | D009336 | — | — | — | — | — | — | 1 | 1 |
| Bites and stings | D001733 | — | — | — | — | — | — | 1 | 1 |
| Thrombotic stroke | D000083244 | — | — | — | — | — | — | 1 | 1 |
| Minimally invasive surgical procedures | D019060 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tenecteplase |
| INN | tenecteplase |
| Description | Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug.
|
| Classification | Enzyme |
| Drug class | enzymes: tissue-type plasminogen activators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108791 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00031 |
| UNII ID | WGD229O42W (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,096 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,916 adverse events reported
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