Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TORISEL | CV Sciences | N-022088 RX | 2007-05-30 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
temsirolimus | ANDA | 2024-02-15 |
torisel | New Drug Application | 2025-03-21 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
renal cell carcinoma | EFO_0000376 | D002292 | — |
Code | Description |
---|---|
J9330 | Injection, temsirolimus, 1 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lymphoma | D008223 | — | C85.9 | 2 | 2 | 1 | 1 | 2 | 8 |
Kidney transplantation | D016030 | — | — | 1 | 1 | 1 | 1 | 4 | 7 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 3 | — | 1 | — | 5 |
Mantle-cell lymphoma | D020522 | — | C83.1 | — | — | 1 | 1 | 2 | 4 |
Graft rejection | D006084 | — | — | 1 | — | — | 1 | — | 2 |
Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 3 | 3 | — | 7 | 15 |
Carcinoma | D002277 | — | C80.0 | 1 | 4 | 3 | — | 7 | 15 |
Syndrome | D013577 | — | — | — | 2 | 1 | — | — | 2 |
Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | 1 | — | — | 2 |
Brain stem infarctions | D020526 | EFO_1000847 | G46.3 | — | 1 | 1 | — | — | 1 |
Sturge-weber syndrome | D013341 | Orphanet_3205 | Q85.89 | — | 1 | 1 | — | — | 1 |
Klippel-trenaunay-weber syndrome | D007715 | EFO_0007334 | Q87.2 | — | 1 | 1 | — | — | 1 |
Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 14 | 5 | — | — | — | 18 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 4 | — | — | — | 5 |
Head and neck neoplasms | D006258 | — | — | 2 | 1 | — | — | 1 | 3 |
Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 3 |
Multiple myeloma | D009101 | — | C90.0 | — | 2 | — | — | — | 2 |
Colorectal neoplasms | D015179 | — | — | 1 | 2 | — | — | — | 2 |
Squamous cell neoplasms | D018307 | — | — | 2 | 1 | — | — | — | 2 |
Non-small-cell lung carcinoma | D002289 | — | — | 2 | 1 | — | — | — | 2 |
Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 2 |
Squamous cell carcinoma | D002294 | — | — | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Port-wine stain | D019339 | — | Q82.5 | 2 | — | — | — | — | 2 |
Capillary hemangioma | D018324 | — | Q82.5 | 2 | — | — | — | — | 2 |
Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
T-cell lymphoma peripheral | D016411 | — | — | 1 | — | — | — | — | 1 |
Lymphoid leukemia | D007945 | — | C91 | 1 | — | — | — | — | 1 |
Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | — | — | — | — | 1 | 1 |
Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | — | — | 1 | 1 |
Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | — | — | — | — | 1 | 1 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
Viremia | D014766 | — | B34.9 | — | — | — | — | 1 | 1 |
Drug common name | Temsirolimus |
INN | temsirolimus |
Description | Temsirolimus, sold under the brand name Torisel, is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the U.S. Food and Drug Administration (FDA) in May 2007, and was also approved by the European Medicines Agency (EMA) in November 2007. It is a derivative and prodrug of sirolimus.
|
Classification | Small molecule |
Drug class | immunosuppressives |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C |
PDB | — |
CAS-ID | 162635-04-3 |
RxCUI | — |
ChEMBL ID | CHEMBL1201182 |
ChEBI ID | 79699 |
PubChem CID | 6918289 |
DrugBank | DB06287 |
UNII ID | 624KN6GM2T (ChemIDplus, GSRS) |