Tyzeka, Sebivo(telbivudine)
Sebivo, Tyzeka (telbivudine) is a small molecule pharmaceutical. Telbivudine was first approved as Tyzeka on 2006-10-25. It is used to treat chronic hepatitis b and hepatitis b in the USA. It has been approved in Europe to treat chronic hepatitis b.
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Indications
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EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hepatitis b | — | D006509 | — |
| chronic hepatitis b | EFO_0004239 | D019694 | B18.1 |
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Clinical Trials
95 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis b | D006509 | — | — | 4 | 10 | 16 | 32 | 16 | 74 |
| Hepatitis | D006505 | — | K75.9 | 4 | 10 | 16 | 32 | 14 | 72 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 4 | 9 | 13 | 30 | 11 | 63 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 3 | 8 | 15 | 27 | 12 | 62 |
| Chronic hepatitis | D006521 | — | K73.9 | 3 | 5 | 9 | 19 | 7 | 40 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 2 | 3 | 2 | 8 |
| Fibrosis | D005355 | — | — | — | 1 | 2 | 4 | — | 7 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | 1 | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | 1 | — | 2 |
| Biliary liver cirrhosis | D008105 | — | K74.3 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis b virus | D006515 | — | — | — | — | 1 | — | 1 | 2 |
| Virus diseases | D014777 | — | B34 | — | 1 | 2 | — | — | 2 |
| Herpesviridae infections | D006566 | EFO_0007309 | B00.4 | — | — | 1 | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | — | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 1 | 1 |
| Sustained virologic response | D000072230 | — | — | — | — | — | — | 1 | 1 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 1 | 1 |
| Essential thrombocythemia | D013920 | — | D47.3 | — | — | — | — | 1 | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | — | — | — | 1 | 1 |
| Thrombocytosis | D013922 | — | D75.83 | — | — | — | — | 1 | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | — | 1 | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Telbivudine |
| INN | telbivudine |
| Description | Telbivudine is a pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase. It has a role as an antiviral drug and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. It is functionally related to a thymine. It is an enantiomer of a thymidine. |
| Classification | Small molecule |
| Drug class | antineoplastics; antivirals (zidovudine group) (exception: edoxudine) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O |
Identifiers
| PDB | — |
| CAS-ID | 3424-98-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL374731 |
| ChEBI ID | 63624 |
| PubChem CID | 159269 |
| DrugBank | DB01265 |
| UNII ID | 2OC4HKD3SF (ChemIDplus, GSRS) |
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1,338 adverse events reported
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