Tpoxx, Tecovirimat siga(tecovirimat)
Tecovirimat Monohydrate, Tpoxx (tecovirimat) is a small molecule pharmaceutical. Tecovirimat was first approved as Tpoxx on 2018-07-13. It is used to treat smallpox in the USA. It has been approved in Europe to treat cowpox, mpox (monkeypox), poxviridae infections, smallpox, and vaccinia.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| animal diseases | D000820 |
Trade Name
FDA
EMA
Tpoxx
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tecovirimat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TPOXX | SIGA Technologies | N-208627 RX | 2018-07-13 | 1 products, RLD, RS |
| TPOXX | SIGA Technologies | N-214518 RX | 2022-05-18 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tpoxx | New Drug Application | 2024-07-03 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| vaccinia | — | D014615 | — |
| smallpox | — | D012899 | B03 |
| poxviridae infections | EFO_0007370 | D011213 | B08.04 |
| cowpox | EFO_0007225 | D015605 | B08.010 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TECOVIRIMAT, TPOXX, SIGA TECHNOLOGIES | |||
| 2025-07-13 | ODE-200 | ||
Patent Expiration
HCPCS
No data
Clinical
Clinical Trials
17 clinical trials
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Virus diseases | D014777 | — | B34 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Orthopoxvirus | D018155 | — | — | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Vaccinia | D014615 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Poxviridae infections | D011213 | EFO_0007370 | B08.04 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tecovirimat |
| INN | tecovirimat |
| Description | Tecovirimat, sold under the brand name Tpoxx among others, is an antiviral medication with activity against orthopoxviruses such as smallpox and mpox. In 2018 it became the first antipoxviral drug approved in the United States.
|
| Classification | Small molecule |
| Drug class | antivirals: antiviral, disrupts viral maturation |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(NN1C(=O)[C@H]2[C@H]3C=C[C@H]([C@@H]4C[C@H]34)[C@H]2C1=O)c1ccc(C(F)(F)F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 816458-31-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1257073 |
| ChEBI ID | — |
| PubChem CID | 16124688 |
| DrugBank | DB12020 |
| UNII ID | F925RR824R (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 1,503 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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102 adverse events reported
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