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Drug ReportsTazobactam
Zosyn, Zerbaxa(tazobactam)
Piperacillin / Tazobactam, Zerbaxa, Zosyn (tazobactam) is a small molecule pharmaceutical. Tazobactam was first approved as Zosyn on 1993-10-22. It has been approved in Europe to treat bacterial infections.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
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FDA approval date
EMA approval date
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Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
Combinations
Piperacillin tazobactam, Zerbaxa, Zosyn (discontinued: Piperacillin tazobactam, Zosyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Piperacillin sodium
+
Tazobactam sodium
Tradename
Company
Number
Date
Products
PIPERACILLIN AND TAZOBACTAM AND SODIUM CHLORIDE IN DUPLEX CONTAINERB. Braun MedicalN-206056 RX2025-04-03
3 products, RLD, RS
ZOSYN IN PLASTIC CONTAINERBaxterN-050750 RX1998-02-24
3 products, RLD, RS
Show 1 discontinued
Ceftolozane sulfate
+
Tazobactam sodium
Tradename
Company
Number
Date
Products
ZERBAXACubist PharmaceuticalsN-206829 RX2014-12-19
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
piperacillin and tazobactamANDA2025-09-08
piperacillin and tazobactam and sodium chlorideNew Drug Application2025-04-17
piperacillin sodium and tazobactam sodiumANDA2024-12-10
piperacillin, tazobactamANDA2024-08-31
zerbaxaNew Drug Application2024-11-04
zosynNew Drug Application2024-12-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pneumoniaEFO_0003106D011014J18
urinary tract infectionsEFO_0003103D014552N39.0
bacterial infections—D001424A49
intraabdominal infections—D059413—
pseudomonas infectionsEFO_0001076D011552A41.52
infectious skin diseases—D012874—
escherichia coli infectionsEFO_1001318D004927B96.20
pelvic infection—D034161—
soft tissue infections—D018461—
streptococcal infectionsEFO_1001476D013290—
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Agency Specific
FDA
EMA
Expiration
Code
CEFTOLOZANE SULFATE / TAZOBACTAM SODIUM, ZERBAXA, CUBIST PHARMS LLC
2025-04-21NPP
2024-12-19GAIN
2019-12-19NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Ceftolozane Sulfate / Tazobactam Sodium, Zerbaxa, Cubist Pharms Llc
101251492035-08-14DP
103764962034-09-09U-2610, U-2611
109330532034-09-09U-3090, U-3091
89068982034-05-28DS, DP
89687532034-03-14U-1672, U-1673, U-3360, U-3361
93207402034-03-14DP
98729062034-03-14DP
104208412034-03-14U-1672, U-2631, U-3360, U-3361
112786222034-03-14U-3335, U-3336
84764252032-09-27DP
86859572032-09-27DPU-36
97243532032-09-07U-2565, U-2566
100289632032-09-07U-2565, U-2566
71292322028-05-15DS, DPU-36, U-1676, U-3360, U-3361
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CG: Beta-lactamase inhibitors, systemic penicillins
— J01CG02: Tazobactam
HCPCS
Code
Description
J0695
Injection, ceftolozane 50 mg and tazobactam 25 mg
J2543
Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
Clinical
Clinical Trials
232 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805EFO_0001420A41.9————11
Acute kidney injuryD058186—N17————11
HemodiafiltrationD017583——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTazobactam
INNtazobactam
Description
Tazobactam is a member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections. It has a role as an antimicrobial agent, an antiinfective agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It is a member of penicillanic acids and a member of triazoles. It is functionally related to a sulbactam. It is a conjugate acid of a tazobactam(1-).
Classification
Small molecule
Drug classbeta-lactamase inhibitors
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Structure (InChI/SMILES or Protein Sequence)
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
Identifiers
PDB—
CAS-ID89786-04-9
RxCUI—
ChEMBL IDCHEMBL404
ChEBI ID9421
PubChem CID123630
DrugBankDB01606
UNII IDSE10G96M8W (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
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€
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Zerbaxa – Merck & Co
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Zosyn – Pfizer
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Estimated US medical usage
Tazobactam
+
Piperacillin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 41,453 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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23,780 adverse events reported
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