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Drug ReportsTazobactam
Zosyn, Zerbaxa(tazobactam)
Piperacillin / Tazobactam, Zerbaxa, Zosyn (tazobactam) is a small molecule pharmaceutical. Tazobactam was first approved as Zosyn on 1993-10-22. It has been approved in Europe to treat bacterial infections.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
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5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
Trade Name
FDA
EMA
Combinations
Piperacillin tazobactam, Zerbaxa, Zosyn (discontinued: Piperacillin tazobactam, Zosyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Piperacillin sodium
+
Tazobactam sodium
Tradename
Company
Number
Date
Products
ZOSYN IN PLASTIC CONTAINERBaxterN-050750 RX1998-02-24
3 products, RLD, RS
Show 1 discontinued
Ceftolozane sulfate
+
Tazobactam sodium
Tradename
Company
Number
Date
Products
ZERBAXACubist PharmaceuticalsN-206829 RX2014-12-19
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
piperacillin and tazobactamANDA2024-11-13
piperacillin sodium and tazobactam sodiumANDA2022-08-26
piperacillin, tazobactamANDA2024-08-31
zerbaxaNew Drug Application2024-11-04
zosynNew Drug Application2024-05-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
pneumoniaEFO_0003106D011014—
urinary tract infectionsEFO_0003103D014552N39.0
bacterial infections—D001424A49
intraabdominal infections—D059413—
pseudomonas infectionsEFO_0001076D011552A41.52
infectious skin diseases—D012874—
escherichia coli infectionsEFO_1001318D004927B96.20
pelvic infection—D034161—
soft tissue infections—D018461—
streptococcal infectionsEFO_1001476D013290—
Show 3 more
Agency Specific
FDA
EMA
Expiration
Code
CEFTOLOZANE SULFATE / TAZOBACTAM SODIUM, ZERBAXA, CUBIST PHARMS LLC
2025-04-21NPP
2024-12-19GAIN
2019-12-19NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Ceftolozane Sulfate / Tazobactam Sodium, Zerbaxa, Cubist Pharms Llc
101251492035-08-14DP
103764962034-09-09U-2610, U-2611
109330532034-09-09U-3090, U-3091
89068982034-05-28DS, DP
89687532034-03-14U-1672, U-1673, U-3360, U-3361
93207402034-03-14DP
98729062034-03-14DP
104208412034-03-14U-1672, U-2631, U-3360, U-3361
112786222034-03-14U-3335, U-3336
84764252032-09-27DP
86859572032-09-27DPU-36
97243532032-09-07U-2565, U-2566
100289632032-09-07U-2565, U-2566
71292322028-05-15DS, DPU-36, U-1676, U-3360, U-3361
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CG: Beta-lactamase inhibitors, systemic penicillins
— J01CG02: Tazobactam
HCPCS
Code
Description
J0695
Injection, ceftolozane 50 mg and tazobactam 25 mg
J2543
Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
Clinical
Clinical Trials
217 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544—3918121756
Communicable diseasesD003141——161261034
PneumoniaD011014EFO_0003106—33135628
SepsisD018805HP_0100806A41.911671428
Bacterial infectionsD001424—A492——51118
NeutropeniaD009503—D70—2—7615
AppendicitisD001064EFO_0007149K3712—5715
FeverD005334HP_0001945R50.9—316313
Critical illnessD016638——11—11013
Febrile neutropeniaD064147———2—7211
Show 45 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthcare-associated pneumoniaD000077299——114—16
PyelonephritisD011704EFO_1001141N10-N16—34——6
NeoplasmsD009369—C80131—15
Covid-19D000086382————1—23
Systemic inflammatory response syndromeD018746EFO_1001478R65.10—11—13
Bacterial pneumoniaD018410EFO_1001272J15.9——3——3
BronchitisD001991—J40—11—12
InflammationD007249MP_0001845———1—12
Acute cholecystitisD041881EFO_1001289K81.0——1—12
CholecystitisD002764HP_0001082K81——1—12
Show 21 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cross infectionD003428———1——23
OsteomyelitisD010019EFO_0003102M8611———2
Gastrointestinal microbiomeD000069196———1———1
Otitis mediaD010033EFO_0004992H66.911———1
OtitisD010031——11———1
Graft vs host diseaseD006086—D89.81—1———1
Pancreatic fistulaD010185———1———1
FistulaD005402———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———4———15
Acute diseaseD000208——1———23
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Disease susceptibilityD004198——————22
PeritonitisD010538EFO_0008588K65————22
HemorrhageD006470MP_0001914R58————22
Drug monitoringD016903——————22
Chronic kidney failureD007676EFO_0003884N18.9————22
EnterococcusD016983——————22
Hematopoietic stem cell transplantationD018380——————22
Heart arrestD006323EFO_0009492I46————22
Gram-positive bacterial infectionsD016908——————22
Cytokine release syndromeD000080424—D89.83————11
Show 77 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTazobactam
INNtazobactam
Description
Tazobactam is a member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicated intra-abdominal infections and complicated urinary tract infections. It has a role as an antimicrobial agent, an antiinfective agent and an EC 3.5.2.6 (beta-lactamase) inhibitor. It is a member of penicillanic acids and a member of triazoles. It is functionally related to a sulbactam. It is a conjugate acid of a tazobactam(1-).
Classification
Small molecule
Drug classbeta-lactamase inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
Identifiers
PDB—
CAS-ID89786-04-9
RxCUI—
ChEMBL IDCHEMBL404
ChEBI ID9421
PubChem CID123630
DrugBankDB01606
UNII IDSE10G96M8W (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Zosyn – Pfizer
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Zerbaxa – Merck & Co
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Tabular view
Estimated US medical usage
Tazobactam
+
Piperacillin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 36,908 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22,023 adverse events reported
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