Tavapadon
Tavapadon is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Abbreviated New Drug Application (ANDA)
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Brand Name | Status | Last Update |
|---|---|---|
| juvmo | New Drug Application | 2026-09-25 |
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Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 5 | 3 | 4 | — | 1 | 13 |
| Central nervous system diseases | D002493 | — | G96.9 | — | — | 2 | — | — | 2 |
| Brain diseases | D001927 | — | G93.40 | — | — | 2 | — | — | 2 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | 2 | — | — | 2 |
| Parkinsonian disorders | D020734 | — | G20.C | — | — | 2 | — | — | 2 |
| Movement disorders | D009069 | EFO_0004280 | G25 | — | — | 2 | — | — | 2 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | 2 | — | — | 2 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tavapadon |
| INN | tavapadon |
| Description | Tavapadon (developmental code names CVL-751, PF-06649751) is a dopamine receptor agonist for the treatment of Parkinson's disease., under development by Cerevel Therapeutics who acquired Tavapadon from Pfizer in 2018. It acts as a selective partial agonist of the dopamine D1 (Ki = 8.54 nM) and D5 receptors. It also shows biased agonism for Gs-coupled signaling. As of July 2021, tavapadon is in phase 3 clinical trials for Parkinson's disease.
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| Classification | Small molecule |
| Drug class | dopamine D1-like receptors (e.g., D1 and D5 subtypes) agonists/partial agonists and potentiators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C |
Identifiers
| PDB | — |
| CAS-ID | 1643489-24-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3697617 |
| ChEBI ID | — |
| PubChem CID | 86764100 |
| DrugBank | — |
| UNII ID | PT4P8MJP8L (ChemIDplus, GSRS) |
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Safety
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