Taurine
Taurine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aminosyn-pf | New Drug Application | 2022-07-21 |
| lingtea | unapproved drug other | 2018-06-24 |
| premasol - sulfite-free (amino acid) | ANDA | 2022-08-04 |
| trophamine | New Drug Application | 2023-11-27 |
Indications
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Agency Specific
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Patent Expiration
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Clinical
Clinical Trials
108 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | 1 | 5 | 6 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | 3 | 2 | 5 |
| Neoplasms | D009369 | — | C80 | — | — | — | 3 | — | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | 1 | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | 1 | 1 | 2 |
| Dentin sensitivity | D003807 | — | — | — | — | — | 1 | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | — | 1 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | — | 1 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | 1 | — | 1 |
| Calcium metabolism disorders | D002128 | EFO_0005769 | E83.5 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | 1 | — | 2 | 3 |
| Cholestasis | D002779 | HP_0001396 | K83.1 | — | — | 1 | — | 1 | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | 1 | — | — | 1 |
| Prehypertension | D058246 | — | — | — | — | 1 | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | 1 | — | — | 1 |
| Xerostomia | D014987 | — | K11.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | 4 | 5 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | 3 | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 2 | 3 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | 2 | 3 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 1 | 1 | — | — | 2 | 3 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 2 | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 2 |
| Homocystinuria | D006712 | HP_0002156 | E72.11 | 2 | 2 | — | — | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 1 | — | — | — | 2 |
| Depression | D003863 | — | F33.9 | — | 1 | — | — | 1 | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | — | — | — | — | 1 |
| Alcohol-related disorders | D019973 | — | F10 | 1 | — | — | — | — | 1 |
| Driving under the influence | D000066448 | — | — | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | 1 | — | — | — | — | 1 |
| Sclerosis | D012598 | — | — | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 7 | 7 |
| Oxidative stress | D018384 | EFO_1001905 | — | — | — | — | — | 3 | 3 |
| Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 2 | 2 |
| Self concept | D012649 | — | — | — | — | — | — | 2 | 2 |
| Blood pressure | D001794 | EFO_0004325 | — | — | — | — | — | 2 | 2 |
| Muscular atrophy | D009133 | HP_0003202 | — | — | — | — | — | 2 | 2 |
| Protein deficiency | D011488 | — | — | — | — | — | — | 2 | 2 |
| Sensitivity training groups | D012681 | — | — | — | — | — | — | 2 | 2 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 2 | 2 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Taurine |
| INN | taurine |
| Description | Taurine is an amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension. It has a role as a human metabolite, an antioxidant, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a glycine receptor agonist, a nutrient and a radical scavenger. It is a conjugate acid of a 2-aminoethanesulfonate. It is a tautomer of a taurine zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCS(=O)(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 107-35-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL239243 |
| ChEBI ID | 15891 |
| PubChem CID | 1123 |
| DrugBank | DB01956 |
| UNII ID | 1EQV5MLY3D (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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155 adverse events reported
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