Tanezumab
Tanezumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against beta-nerve growth factor.
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Clinical
Clinical Trials
40 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | 3 | — | — | 3 |
| Cancer pain | D000072716 | — | G89.3 | — | — | 2 | — | — | 2 |
| Low back pain | D017116 | — | M54.5 | — | — | 2 | — | — | 2 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | 1 | — | — | 1 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | 1 | — | — | 1 |
| Back pain | D001416 | — | M54 | — | — | 1 | — | — | 1 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | — | — | 1 | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tanezumab |
| INN | tanezumab |
| Description | Tanezumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >4EDW:H|tanezumab Fab heavy chain
QVQLQESGPGLVKPSETLSLTCTVSGFSLIGYDLNWIRQPPGKGLEWIGIIWGDGTTDYNSAVKSRVTISKDTSKNQFSL
KLSSVTAADTAVYYCARGGYWYATSYYFDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKTSHHHHHHG
>4EDW:L|tanezumab Fab light chain
DIQMTQSPSSLSASVGDRVTITCRASQSISNNLNWYQQKPGKAPKLLIYYTSRFHSGVPSRFSGSGSGTDFTFTISSLQP
EDIATYYCQQEHTLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 4EDW |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108567 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12335 |
| UNII ID | EQL0E9GCX1 (ChemIDplus, GSRS) |
Target
Agency Approved
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Safety
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89 adverse events reported
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