Tanespimycin
Tanespimycin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against heat shock protein HSP 90-alpha. In addition, it is known to target hepatocyte growth factor receptor.
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Commercial
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Clinical
Clinical Trials
54 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 2 | 1 | 2 | — | — | 4 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 19 | 2 | — | — | — | 20 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 5 | 1 | — | — | — | 6 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 4 | — | — | — | 6 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 4 | 1 | — | — | — | 5 |
| Hodgkin disease | D006689 | — | C81 | 3 | 2 | — | — | — | 5 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 2 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 3 | 1 | — | — | — | 4 |
| Melanoma | D008545 | — | — | 1 | 3 | — | — | — | 4 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 2 | — | — | — | 3 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 8 | — | — | — | — | 8 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 8 | — | — | — | — | 8 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 5 | — | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 5 | — | — | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 5 | — | — | — | — | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 4 | — | — | — | — | 4 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 4 | — | — | — | — | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | — | — | — | — | 4 |
| Burkitt lymphoma | D002051 | — | C83.7 | 4 | — | — | — | — | 4 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | 4 | — | — | — | — | 4 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tanespimycin |
| INN | tanespimycin |
| Description | Tanespimycin (17-N-allylamino-17-demethoxygeldanamycin, 17-AAG) is a derivative of the antibiotic geldanamycin that is being studied in the treatment of cancer, specifically in younger patients with certain types of leukemia or solid tumors, especially kidney tumors.
|
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)NC(=CC1=O)C2=O |
Identifiers
| PDB | — |
| CAS-ID | 75747-14-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL109480 |
| ChEBI ID | 64153 |
| PubChem CID | 6440175 |
| DrugBank | — |
| UNII ID | 4GY0AVT3L4 (ChemIDplus, GSRS) |
Target
Agency Approved
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
HSP90AA1
Gene synonyms
HSP90A, HSPC1, HSPCA
NCBI Gene ID
Protein name
heat shock protein HSP 90-alpha
Protein synonyms
epididymis luminal secretory protein 52, epididymis secretory sperm binding protein Li 65p, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein 90kDa alpha family class A member 1, HSP 86, HSP86, LAP-2, Lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
Uniprot ID
Mouse ortholog
Hsp90aa1 (15519)
heat shock protein HSP 90-alpha (P07901)
Alternate
MET
MET
Organism
Homo sapiens
Gene name
MET
Gene synonyms
NCBI Gene ID
Protein name
hepatocyte growth factor receptor
Protein synonyms
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Uniprot ID
Mouse ortholog
Met (17295)
hepatocyte growth factor receptor (Q62125)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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54 adverse events reported
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