Tamsulosin
Jalyn, Tamsulosin (tamsulosin) is a small molecule pharmaceutical. Tamsulosin was first approved as Flomax on 1997-04-15. It is used to treat prostatic hyperplasia in the USA. The pharmaceutical is active against alpha-1A adrenergic receptor, alpha-1D adrenergic receptor, and alpha-1B adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Tamsulosin (discontinued: Flomax, Tamsulosin)
CombinationsDutasteride tamsulosin, Jalyn (discontinued: Dutasteride tamsulosin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tamsulosin hydrochloride
Dutasteride
+
Tamsulosin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| JALYN | Waylis Therapeutics | N-022460 RX | 2010-06-14 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dutasteride and tamsulosin hydrochloride | ANDA | 2024-11-28 |
| flomax | New Drug Application | 2025-01-02 |
| jalyn | New Drug Application | 2024-07-18 |
| tamsulosin hydrochloride | ANDA | 2025-08-28 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| prostatic hyperplasia | EFO_0000284 | D011470 | N40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04C: Drugs used in benign prostatic hypertrophy
— G04CA: Alpha-adrenoreceptor antagonists, benign prostatic hypertrophy
— G04CA02: Tamsulosin
— G04CA52: Tamsulosin and dutasteride
— G04CA53: Tamsulosin and solifenacin
— G04CA54: Tamsulosin and tadalafil
HCPCS
No data
Clinical
Clinical Trials
271 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 26 | 8 | 24 | 28 | 27 | 112 |
| Hyperplasia | D006965 | EFO_0000536 | — | 10 | 1 | 7 | 7 | 12 | 37 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | 2 | 8 | 8 | 11 | 7 | 34 |
| Urinary retention | D016055 | — | R33 | 5 | 7 | 9 | 8 | 4 | 30 |
| Ureteral calculi | D014514 | — | — | 2 | — | 3 | 7 | 8 | 20 |
| Ureterolithiasis | D053039 | EFO_1001228 | N20.1 | 1 | 1 | 2 | 6 | 8 | 18 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 2 | 5 | 8 | 15 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 4 | 1 | 1 | 9 | — | 14 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | 5 | 4 | 10 |
| Calculi | D002137 | — | — | — | — | 1 | 5 | 4 | 10 |
Show 29 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 5 | 1 | 4 | — | 1 | 11 |
| Urologic diseases | D014570 | — | N39.9 | 2 | — | 2 | — | 1 | 5 |
| Urination disorders | D014555 | — | — | 1 | — | 1 | — | — | 2 |
| Male urogenital diseases | D052801 | — | — | — | 1 | 1 | — | — | 1 |
| Drug therapy | D004358 | — | — | — | — | 1 | — | — | 1 |
| Minimally invasive surgical procedures | D019060 | — | — | — | — | 1 | — | — | 1 |
| Ureteroscopy | D018666 | — | — | — | — | 1 | — | — | 1 |
| Epidural analgesia | D015360 | — | — | — | — | 1 | — | — | 1 |
| Thoracic surgical procedures | D019616 | — | — | — | — | 1 | — | — | 1 |
| Urinary catheterization | D014546 | — | — | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Urinary bladder neck obstruction | D001748 | EFO_1000840 | N32.0 | 1 | 1 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Macular edema | D008269 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 21 | — | — | — | — | 21 |
| Pharmacokinetics | D010599 | — | — | 5 | — | — | — | — | 5 |
| Hypertrophy | D006984 | EFO_0002460 | — | 1 | — | — | — | 1 | 2 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | — | 1 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 1 | 1 |
| Masturbation | D008418 | — | — | — | — | — | — | 1 | 1 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | — | — | — | — | — | 1 | 1 |
| Eyelid diseases | D005141 | EFO_0009547 | H02.9 | — | — | — | — | 1 | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | — | — | 1 | 1 |
| Capsule opacification | D058442 | — | H26.4 | — | — | — | — | 1 | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tamsulosin |
| INN | tamsulosin |
| Description | Tamsulosin is a 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It is a conjugate base of a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin. |
| Classification | Small molecule |
| Drug class | α1 blocker |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1 |
Identifiers
| PDB | — |
| CAS-ID | 106133-20-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL836 |
| ChEBI ID | 9398 |
| PubChem CID | 129211 |
| DrugBank | DB00706 |
| UNII ID | G3P28OML5I (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1A
ADRA1A
ADRA1D
ADRA1D
ADRA1B
ADRA1B
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Tamsulosin
+
Dutasteride
Total medical expenditures per year (USD, in millions)
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Tamsulosin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20,165 adverse events reported
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