Tafluprost
Tafluprost, Zioptan (tafluprost) is a small molecule pharmaceutical. Tafluprost was first approved as Zioptan on 2012-02-10. It is used to treat open-angle glaucoma in the USA. The pharmaceutical is active against prostaglandin F2-alpha receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Zioptan (generic drugs available since 2019-08-19)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tafluprost
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZIOPTAN | Thea Pharma | N-202514 RX | 2012-02-10 | 1 products, RLD, RS |
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| open-angle glaucoma | EFO_0004190 | D005902 | H40.1 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 1 | 8 | 8 | 4 | 21 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | 2 | 1 | 8 | 9 | 1 | 20 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | 1 | 3 | 7 | 1 | 12 |
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tafluprost |
| INN | tafluprost |
| Description | Tafluprost (trade names Taflotan by Santen Pharmaceutical, Zioptan by Merck in the US and Saflutan by Mundipharma in Australia) is a prostaglandin analogue. It is used topically (as eye drops) to control the progression of open-angle glaucoma and in the management of ocular hypertension, alone or in combination with other medication. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.
|
| Classification | Small molecule |
| Drug class | prostaglandins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(F)(F)COc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 209860-87-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1963683 |
| ChEBI ID | 66899 |
| PubChem CID | 6433101 |
| DrugBank | DB08819 |
| UNII ID | 1O6WQ6T7G3 (ChemIDplus, GSRS) |
Target
Agency Approved
PTGFR
PTGFR
Organism
Homo sapiens
Gene name
PTGFR
Gene synonyms
NCBI Gene ID
Protein name
prostaglandin F2-alpha receptor
Protein synonyms
FP prostanoid receptor, PGF receptor, PGF2 alpha receptor, prostaglandin receptor (2-alpha), Prostanoid FP receptor
Uniprot ID
Mouse ortholog
Ptgfr (19220)
prostaglandin F2-alpha receptor (P43117)
Alternate
No data
Variants
No data
Financial
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Zioptan – Akorn
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Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 725 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,676 adverse events reported
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