Tafenoquine
Arakoda, Krintafel (tafenoquine) is a small molecule pharmaceutical. Tafenoquine was first approved as Krintafel on 2018-07-20. It is used to treat malaria in the USA.
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EMA approval date
Patent expiration date
Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
Trade Name
FDA
EMA
Arakoda, Krintafel
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Tafenoquine succinate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ARAKODA | 60 Degrees Pharmaceuticals | N-210607 RX | 2018-08-08 | 1 products, RLD, RS |
| KRINTAFEL | GSK | N-210795 RX | 2018-07-20 | 1 products, RLD, RS |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| malaria | EFO_0001068 | D008288 | B54 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
TAFENOQUINE SUCCINATE, KRINTAFEL, GLAXOSMITHKLINE | |||
| 2025-07-20 | ODE-201 | ||
HCPCS
No data
Clinical
Clinical Trials
38 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vivax malaria | D016780 | EFO_0007445 | B51 | 4 | 3 | 6 | 5 | 4 | 22 |
| Malaria | D008288 | EFO_0001068 | B54 | 5 | 5 | 5 | 2 | 1 | 18 |
| Recurrence | D012008 | — | — | — | — | — | 1 | — | 1 |
| Antibiotic prophylaxis | D019072 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemolysis | D006461 | — | — | — | — | 1 | — | — | 1 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Falciparum malaria | D016778 | EFO_0007444 | B50 | — | 3 | — | — | — | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | — | — | — | 2 |
| Babesiosis | D001404 | EFO_0007162 | B60.0 | — | 1 | — | — | 1 | 2 |
| Parasitemia | D018512 | — | — | — | 1 | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | — | — | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | 1 | — | — | — | 1 |
| Disease progression | D018450 | — | — | — | 1 | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
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Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glucosephosphate dehydrogenase deficiency | D005955 | EFO_0007287 | — | — | — | — | — | 2 | 2 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tafenoquine |
| INN | tafenoquine |
| Description | N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine is an aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group. It is a member of (trifluoromethyl)benzenes, an aminoquinoline, an aromatic ether, a primary amino compound and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | Antimalarial |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 106635-80-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL298470 |
| ChEBI ID | — |
| PubChem CID | 115358 |
| DrugBank | DB06608 |
| UNII ID | 262P8GS9L9 (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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58 adverse events reported
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