Tacrine
Cognex (tacrine) is a small molecule pharmaceutical. Tacrine was first approved as Cognex on 1993-09-09. It is used to treat alzheimer disease in the USA. The pharmaceutical is active against cholinesterase and acetylcholinesterase. In addition, it is known to target muscarinic acetylcholine receptor M2 and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alzheimer disease | EFO_0000249 | D000544 | F03 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| S0014 | Tacrine hydrochloride, 10 mg |
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 3 | — | 3 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | 1 | 2 | 3 |
| Proteinuria | D011507 | — | R80 | — | — | — | 1 | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | 1 | — | 1 |
| Cardiovascular abnormalities | D018376 | EFO_0003848 | — | — | — | — | 1 | — | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | 1 | — | 1 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | 1 | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | 1 | — | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | 1 | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 1 | — | 1 |
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | — | 1 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | — | — | — | — | 1 | 1 |
| Hip dislocation | D006617 | — | S73.00 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 1 | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | — | — | — | 1 | 1 |
| Congenital hand deformities | D006228 | — | — | — | — | — | — | 1 | 1 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | — | 1 | 1 |
| Noncommunicable diseases | D000073296 | — | — | — | — | — | — | 1 | 1 |
| Chronic disease | D002908 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Tacrine |
| INN | tacrine |
| Description | Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+). |
| Classification | Small molecule |
| Drug class | acridine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1c2c(nc3ccccc13)CCCC2 |
Identifiers
| PDB | — |
| CAS-ID | 321-64-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL95 |
| ChEBI ID | 45980 |
| PubChem CID | — |
| DrugBank | DB00382 |
| UNII ID | 4VX7YNB537 (ChemIDplus, GSRS) |
Target
Alternate
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Variants
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Financial
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Estimated US medical usage
Tacrine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,481 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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31 adverse events reported
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