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Drug ReportsTROPIFEXOR
TROPIFEXOR
Tropifexor is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bile acid receptor.
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Variants
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Events Timeline
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Commercial
No data
Clinical
No data
Drug
General
Drug common nameTROPIFEXOR
INNtropifexor
Description
Tropifexor is an investigational drug that acts as an agonist of the farnesoid X receptor (FXR). It was discovered by researchers from Novartis and Genomics Institute of the Novartis Research Foundation. Its synthesis and pharmacological properties were published in 2017. It was developed for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH). In combination with cenicriviroc, a CCR2 and CCR5 receptor inhibitor, it is undergoing a phase II clinical trial for NASH and liver fibrosis.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1cc(F)c2nc(N3[C@H]4CC[C@@H]3C[C@H](OCc3c(-c5ccccc5OC(F)(F)F)noc3C3CC3)C4)sc2c1
Identifiers
PDB
CAS-ID1383816-29-2
RxCUI
ChEMBL IDCHEMBL4298169
ChEBI ID
PubChem CID121418176
DrugBank
UNII IDNMZ08KM76Z (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR1H4
NR1H4
Organism
Homo sapiens
Gene name
NR1H4
Gene synonyms
BAR, FXR, HRR1, RIP14
NCBI Gene ID
Protein name
bile acid receptor
Protein synonyms
farnesoid X nuclear receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Uniprot ID
Mouse ortholog
Nr1h4 (20186)
bile acid receptor (Q60641)
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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