TOZASERTIB
Tozasertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against aurora kinase C, aurora kinase A, and aurora kinase B.
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Commercial
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 1 | — | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 2 | — | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | — | — | — | — | 1 |
| Philadelphia chromosome | D010677 | — | — | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Blast crisis | D001752 | — | — | 1 | — | — | — | — | 1 |
| B-cell leukemia | D015448 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TOZASERTIB |
| INN | tozasertib |
| Description | N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide is a N-arylpiperazine. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 639089-54-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL572878 |
| ChEBI ID | — |
| PubChem CID | 5494449 |
| DrugBank | — |
| UNII ID | 234335M86K (ChemIDplus, GSRS) |
Target
Agency Approved
AURKB
AURKB
Organism
Homo sapiens
Gene name
AURKB
Gene synonyms
AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5
NCBI Gene ID
Protein name
aurora kinase B
Protein synonyms
AIM-1, ARK-2, Aurora 1, aurora kinase B-Sv1, aurora kinase B-Sv2, Aurora- and IPL1-like midbody-associated protein 1, aurora- and Ipl1-like midbody-associated protein 1 homolog, aurora-1, aurora-B, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, protein phosphatase 1, regulatory subunit 48, serine/threonine kinase 12, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, STK-1
Uniprot ID
Mouse ortholog
Aurkb (20877)
aurora kinase B (Q8C6C1)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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