TOSEDOSTAT
Tosedostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 4 | — | — | — | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 4 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 4 | — | — | — | 5 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 3 | — | — | — | 4 |
| Preleukemia | D011289 | — | — | 2 | 3 | — | — | — | 4 |
| Syndrome | D013577 | — | — | 1 | 2 | — | — | — | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TOSEDOSTAT |
| INN | tosedostat |
| Description | (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-2-phenylacetic acid cyclopentyl ester is a secondary carboxamide, a hydroxamic acid and a carboxylic ester. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@@H](C(=O)N[C@H](C(=O)OC1CCCC1)c1ccccc1)[C@H](O)C(=O)NO |
Identifiers
| PDB | — |
| CAS-ID | 238750-77-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103847 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | KZK563J2UW (ChemIDplus, GSRS) |
Target
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Trends
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Additional graphs summarizing 172 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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11 adverse events reported
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